RRC ID |
2234
|
著者 |
Chikashige Y, Tsutsumi C, Yamane M, Okamasa K, Haraguchi T, Hiraoka Y.
|
タイトル |
Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.
|
ジャーナル |
Cell
|
Abstract |
In many organisms, meiotic chromosomes are bundled at their telomeres to form a "bouquet" arrangement. The bouquet formation plays an important role in homologous chromosome pairing and therefore progression of meiosis. As meiotic telomere clustering occurs in response to mating pheromone signaling in fission yeast, we looked for factors essential for bouquet formation among genes induced under mating pheromone signaling. This genome-wide search identified two proteins, Bqt1 and Bqt2, that connect telomeres to the spindle-pole body (SPB; the centrosome equivalent in fungi). Neither Bqt1 nor Bqt2 alone functions as a connector, but together the two proteins form a bridge between Rap1 (a telomere protein) and Sad1 (an SPB protein). Significantly, when both Bqt1 and Bqt2 are ectopically expressed in mitotic cells, they also form a bridge between Rap1 and Sad1. Thus, a complex including Bqt1 and Bqt2 is essential for connecting telomeres to the SPB.
|
巻・号 |
125(1)
|
ページ |
59-69
|
公開日 |
2006-4-7
|
DOI |
10.1016/j.cell.2006.01.048
|
PII |
S0092-8674(06)00318-7
|
PMID |
16615890
|
MeSH |
Cell Nucleus / metabolism
Chromosome Pairing*
Chromosomes, Fungal / metabolism*
Equisetum / metabolism
Genome, Fungal / genetics
Meiosis*
Models, Genetic
Phenotype
Prophase
Schizosaccharomyces / cytology
Schizosaccharomyces pombe Proteins / metabolism*
Shelterin Complex
Telomere / metabolism*
Telomere-Binding Proteins / metabolism*
|
IF |
38.637
|
引用数 |
234
|
WOS 分野
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
リソース情報 |
酵母 |
|