RRC ID 2234
著者 Chikashige Y, Tsutsumi C, Yamane M, Okamasa K, Haraguchi T, Hiraoka Y.
タイトル Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.
ジャーナル Cell
Abstract In many organisms, meiotic chromosomes are bundled at their telomeres to form a "bouquet" arrangement. The bouquet formation plays an important role in homologous chromosome pairing and therefore progression of meiosis. As meiotic telomere clustering occurs in response to mating pheromone signaling in fission yeast, we looked for factors essential for bouquet formation among genes induced under mating pheromone signaling. This genome-wide search identified two proteins, Bqt1 and Bqt2, that connect telomeres to the spindle-pole body (SPB; the centrosome equivalent in fungi). Neither Bqt1 nor Bqt2 alone functions as a connector, but together the two proteins form a bridge between Rap1 (a telomere protein) and Sad1 (an SPB protein). Significantly, when both Bqt1 and Bqt2 are ectopically expressed in mitotic cells, they also form a bridge between Rap1 and Sad1. Thus, a complex including Bqt1 and Bqt2 is essential for connecting telomeres to the SPB.
巻・号 125(1)
ページ 59-69
公開日 2006-4-7
DOI 10.1016/j.cell.2006.01.048
PII S0092-8674(06)00318-7
PMID 16615890
MeSH Cell Nucleus / metabolism Chromosome Pairing* Chromosomes, Fungal / metabolism* Equisetum / metabolism Genome, Fungal / genetics Meiosis* Models, Genetic Phenotype Prophase Schizosaccharomyces / cytology Schizosaccharomyces pombe Proteins / metabolism* Shelterin Complex Telomere / metabolism* Telomere-Binding Proteins / metabolism*
IF 38.637
引用数 234
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
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