| RRC ID |
2412
|
| Author |
Niwa Y, Masamizu Y, Liu T, Nakayama R, Deng CX, Kageyama R.
|
| Title |
The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock.
|
| Journal |
Dev Cell
|
| Abstract |
Periodic formation of somites is controlled by the segmentation clock, where the oscillator Hes7 regulates cyclic expression of the Notch modulator Lunatic fringe. Here, we show that Hes7 also regulates cyclic expression of the Fgf signaling inhibitor Dusp4 and links Notch and Fgf oscillations in phase. Strikingly, inactivation of Notch signaling abolishes the propagation but allows the initiation of Hes7 oscillation. By contrast, transient inactivation of Fgf signaling abolishes the initiation, whereas sustained inactivation abolishes both the initiation and propagation of Hes7 oscillation. We thus propose that Hes7 oscillation is initiated by Fgf signaling and propagated/maintained anteriorly by Notch signaling.
|
| Volume |
13(2)
|
| Pages |
298-304
|
| Published |
2007-8-1
|
| DOI |
10.1016/j.devcel.2007.07.013
|
| PII |
S1534-5807(07)00274-2
|
| PMID |
17681139
|
| MeSH |
Animals
Basic Helix-Loop-Helix Transcription Factors / genetics
Basic Helix-Loop-Helix Transcription Factors / metabolism*
Biological Clocks* / drug effects
Cleavage Stage, Ovum / drug effects
Cleavage Stage, Ovum / metabolism*
Fibroblast Growth Factors / antagonists & inhibitors
Fibroblast Growth Factors / metabolism*
Gene Expression Regulation, Developmental / drug effects
Mice
Mice, Knockout
Models, Biological
Mutation / genetics
Pyrroles / pharmacology
Receptors, Notch / antagonists & inhibitors
Receptors, Notch / metabolism*
Signal Transduction* / drug effects
Somites / drug effects
Somites / metabolism*
Triglycerides / pharmacology
gamma-Aminobutyric Acid / analogs & derivatives
gamma-Aminobutyric Acid / pharmacology
|
| IF |
10.092
|
| Times Cited |
131
|
|
WOS Category
|
DEVELOPMENTAL BIOLOGY
CELL BIOLOGY
|
| Resource |
| Mice |
RBRC01071
RBRC01101 |
