RRC ID 275
Author Igaki T, Kanda H, Yamamoto-Goto Y, Kanuka H, Kuranaga E, Aigaki T, Miura M.
Title Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway.
Journal EMBO J
Abstract Drosophila provides a powerful genetic model for studying the in vivo regulation of cell death. In our large-scale gain-of-function screen, we identified Eiger, the first invertebrate tumor necrosis factor (TNF) superfamily ligand that can induce cell death. Eiger is a type II transmembrane protein with a C-terminal TNF homology domain. It is predominantly expressed in the nervous system. Genetic evidence shows that Eiger induces cell death by activating the Drosophila JNK pathway. Although this cell death process is blocked by Drosophila inhibitor-of-apoptosis protein 1 (DIAP1), it does not require caspase activity. We also show genetically that Eiger is a physiological ligand for the Drosophila JNK pathway. Our findings demonstrate that Eiger can initiate cell death through an IAP-sensitive cell death pathway via JNK signaling.
Volume 21(12)
Pages 3009-18
Published 2002-6-17
DOI 10.1093/emboj/cdf306
PMID 12065414
PMC PMC126061
MeSH Amino Acid Sequence Animals Apoptosis / physiology Drosophila Proteins / chemistry Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / anatomy & histology Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Drosophila melanogaster / physiology* Embryo, Nonmammalian / anatomy & histology Embryo, Nonmammalian / physiology Genes, Insect In Situ Hybridization Inhibitor of Apoptosis Proteins Insect Proteins / physiology JNK Mitogen-Activated Protein Kinases Ligands MAP Kinase Signaling System / physiology* Membrane Proteins / chemistry Membrane Proteins / genetics Membrane Proteins / metabolism* Mitogen-Activated Protein Kinases / metabolism* Molecular Sequence Data Multigene Family Peptides / genetics Peptides / metabolism Phenotype Photoreceptor Cells, Invertebrate / growth & development Proteins* Sequence Alignment Tumor Necrosis Factor-alpha / genetics Tumor Necrosis Factor-alpha / metabolism*
IF 9.889
Times Cited 312