RRC ID 28627
著者 Nishioka N, Inoue K, Adachi K, Kiyonari H, Ota M, Ralston A, Yabuta N, Hirahara S, Stephenson RO, Ogonuki N, Makita R, Kurihara H, Morin-Kensicki EM, Nojima H, Rossant J, Nakao K, Niwa H, Sasaki H.
タイトル The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass.
ジャーナル Dev Cell
Abstract Outside cells of the preimplantation mouse embryo form the trophectoderm (TE), a process requiring the transcription factor Tead4. Here, we show that transcriptionally active Tead4 can induce Cdx2 and other trophoblast genes in parallel in embryonic stem cells. In embryos, the Tead4 coactivator protein Yap localizes to nuclei of outside cells, and modulation of Tead4 or Yap activity leads to changes in Cdx2 expression. In inside cells, Yap is phosphorylated and cytoplasmic, and this involves the Hippo signaling pathway component Lats. We propose that active Tead4 promotes TE development in outside cells, whereas Tead4 activity is suppressed in inside cells by cell contact- and Lats-mediated inhibition of nuclear Yap localization. Thus, differential signaling between inside and outside cell populations leads to changes in cell fate specification during TE formation.
巻・号 16(3)
ページ 398-410
公開日 2009-3-1
DOI 10.1016/j.devcel.2009.02.003
PII S1534-5807(09)00077-X
PMID 19289085
MeSH Adaptor Proteins, Signal Transducing / genetics Adaptor Proteins, Signal Transducing / metabolism* Animals Blastocyst Inner Cell Mass / metabolism* CDX2 Transcription Factor Cell Cycle Proteins Cells, Cultured DNA-Binding Proteins / genetics DNA-Binding Proteins / metabolism* Ectoderm / metabolism Embryo Culture Techniques Embryonic Stem Cells / metabolism Female Gene Expression Regulation, Developmental Homeodomain Proteins / genetics Homeodomain Proteins / metabolism Mice Mice, Inbred C57BL Mice, Inbred DBA Mice, Mutant Strains Mice, Transgenic Models, Biological Muscle Proteins / genetics Muscle Proteins / metabolism* Phosphoproteins / genetics Phosphoproteins / metabolism* Pregnancy Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism* Signal Transduction TEA Domain Transcription Factors Transcription Factors / genetics Transcription Factors / metabolism* Trophoblasts / metabolism* YAP-Signaling Proteins
IF 10.092
引用数 532
WOS 分野 DEVELOPMENTAL BIOLOGY CELL BIOLOGY
リソース情報
遺伝子材料 pcDNA3.1-pA83-beta-globin (RDB12183) pcDNA3.1-pA83-Foxa2VP16 (RDB12184) pcDNA3.1-pA83-Tead4 (RDB12185) pcDNA3.1-pA83-Tead4VP16 (RDB12186) pcDNA3.1-pA83-Tead4EnR (RDB12187) pcDNA3.1-pA83-Tead1VP16 (RDB12188) pcDNA3.1-pA83-Ssdp1 (RDB12189) pcDNA3.1-pA83-HA-Yap (RDB12190) pcDNA3.1-pA83-HA-Yap-delta TeadBD (RDB12191) pcDNA3.1-pA83-HA-Yap-delta AD (RDB12192) pcDNA3.1-pA83-HA-TAZ (RDB12193) pcDNA3.1-pA83-HA-Yap-S112A (RDB12194) pcDNA3.1-pA83-dnYap (RDB12195) pcDNA3.1-pA83-Lats2 (RDB12200) pcDNA3.1-pA83-Lats2KD (RDB12201) pCMV-Gal4(BD) (RDB12196) pCMV-Gal4-Tead4C (RDB12197) pG4-TK-Luc (RDB12198) pcDNA3.1-pA83-NDR1 (RDB12199).