論文 - 詳細
| RRC ID | 28901 |
|---|---|
| 著者 | Lee KS, Wu Z, Song Y, Mitra SS, Feroze AH, Cheshier SH, Lu B. |
| タイトル | Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway. |
| ジャーナル | Genes Dev |
| Abstract |
The self-renewal versus differentiation choice of Drosophila and mammalian neural stem cells (NSCs) requires Notch (N) signaling. How N regulates NSC behavior is not well understood. Here we show that canonical N signaling cooperates with a noncanonical N signaling pathway to mediate N-directed NSC regulation. In the noncanonical pathway, N interacts with PTEN-induced kinase 1 (PINK1) to influence mitochondrial function, activating mechanistic target of rapamycin complex 2 (mTORC2)/AKT signaling. Importantly, attenuating noncanonical N signaling preferentially impaired the maintenance of Drosophila and human cancer stem cell-like tumor-forming cells. Our results emphasize the importance of mitochondria to N and NSC biology, with important implications for diseases associated with aberrant N signaling. |
| 巻・号 | 27(24) |
| ページ | 2642-7 |
| 公開日 | 2013-12-15 |
| DOI | 10.1101/gad.225169.113 |
| PII | 27/24/2642 |
| PMID | 24352421 |
| PMC | PMC3877754 |
| MeSH | Animals Brain Neoplasms / physiopathology Cell Line, Tumor Cell Proliferation Drosophila melanogaster / genetics Drosophila melanogaster / metabolism Gene Expression Regulation Humans Mechanistic Target of Rapamycin Complex 2 Microscopy, Electron, Transmission Mitochondria / enzymology Mitochondria / metabolism* Mitochondria / ultrastructure Multiprotein Complexes / genetics Multiprotein Complexes / metabolism* Mutation Neoplastic Stem Cells / metabolism* Protein Kinases / genetics Protein Kinases / metabolism* RNA Interference Receptors, Notch / metabolism* Signal Transduction* TOR Serine-Threonine Kinases / genetics TOR Serine-Threonine Kinases / metabolism* |
| IF | 9.527 |
| 引用数 | 45 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY GENETICS & HEREDITY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 2286R-3 |