Reference - Detail
| RRC ID | 28969 |
|---|---|
| Author | Segall JE, Kuspa A, Shaulsky G, Ecke M, Maeda M, Gaskins C, Firtel RA, Loomis WF. |
| Title | A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium. |
| Journal | J Cell Biol |
| Abstract |
Analysis of a developmental mutant in Dictyostelium discoideum which is unable to initiate morphogenesis has shown that a protein kinase of the MAP kinase/ERK family affects relay of the cAMP chemotactic signal and cell differentiation. Strains in which the locus encoding ERK2 is disrupted respond to a pulse of cAMP by synthesizing cGMP normally but show little synthesis of cAMP. Since mutant cells lacking ERK2 contain normal levels of both the cytosolic regulator of adenylyl cyclase (CRAC) and manganese-activatable adenylyl cyclase, it appears that this kinase is important for receptor-mediated activation of adenylyl cyclase. |
| Volume | 128(3) |
| Pages | 405-13 |
| Published | 1995-2-1 |
| DOI | 10.1083/jcb.128.3.405 |
| PMID | 7844154 |
| PMC | PMC2120359 |
| MeSH | Adenylyl Cyclases / metabolism* Amino Acid Sequence Animals Dictyostelium / enzymology* Enzyme Activation GTP-Binding Proteins / metabolism Mitogen-Activated Protein Kinase 1 Molecular Sequence Data Mutation Phenotype Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism* Protein-Tyrosine Kinases / genetics Protein-Tyrosine Kinases / metabolism* Receptors, Cytoplasmic and Nuclear / metabolism* Sequence Homology, Amino Acid |
| IF | 8.811 |
| Times Cited | 144 |
| WOS Category | CELL BIOLOGY |
| Resource | |
| Cellular slime molds | S00409 |