RRC ID 28969
著者 Segall JE, Kuspa A, Shaulsky G, Ecke M, Maeda M, Gaskins C, Firtel RA, Loomis WF.
タイトル A MAP kinase necessary for receptor-mediated activation of adenylyl cyclase in Dictyostelium.
ジャーナル J Cell Biol
Abstract Analysis of a developmental mutant in Dictyostelium discoideum which is unable to initiate morphogenesis has shown that a protein kinase of the MAP kinase/ERK family affects relay of the cAMP chemotactic signal and cell differentiation. Strains in which the locus encoding ERK2 is disrupted respond to a pulse of cAMP by synthesizing cGMP normally but show little synthesis of cAMP. Since mutant cells lacking ERK2 contain normal levels of both the cytosolic regulator of adenylyl cyclase (CRAC) and manganese-activatable adenylyl cyclase, it appears that this kinase is important for receptor-mediated activation of adenylyl cyclase.
巻・号 128(3)
ページ 405-13
公開日 1995-2-1
DOI 10.1083/jcb.128.3.405
PMID 7844154
PMC PMC2120359
MeSH Adenylyl Cyclases / metabolism* Amino Acid Sequence Animals Dictyostelium / enzymology* Enzyme Activation GTP-Binding Proteins / metabolism Mitogen-Activated Protein Kinase 1 Molecular Sequence Data Mutation Phenotype Protein Serine-Threonine Kinases / genetics Protein Serine-Threonine Kinases / metabolism* Protein-Tyrosine Kinases / genetics Protein-Tyrosine Kinases / metabolism* Receptors, Cytoplasmic and Nuclear / metabolism* Sequence Homology, Amino Acid
IF 8.811
引用数 144
WOS 分野 CELL BIOLOGY
リソース情報
細胞性粘菌 S00409