論文 - 詳細
| RRC ID | 291 |
|---|---|
| 著者 | Tamura T, Chiang AS, Ito N, Liu HP, Horiuchi J, Tully T, Saitoe M. |
| タイトル | Aging specifically impairs amnesiac-dependent memory in Drosophila. |
| ジャーナル | Neuron |
| Abstract |
Age-related memory impairment (AMI) is observed in many species. However, it is uncertain whether AMI results from a specific or a nonspecific decay in memory processing. In Drosophila, memory acquired after a single olfactory conditioning paradigm has three distinct phases: short-term memory (STM), middle-term memory (MTM), and longer-lasting anesthesia-resistant memory (ARM). Here, we demonstrate that age-related defects in olfactory memory are identical to those of the MTM mutant amnesiac (amn). Furthermore, amn flies do not exhibit an age-dependent decrease in memory, in contrast to other memory mutants. The absence of AMI in amn flies is restored by expression of an amn transgene predominantly in DPM cells. Thus, we propose that AMI in flies results from a specific decrease in amn-dependent MTM. |
| 巻・号 | 40(5) |
| ページ | 1003-11 |
| 公開日 | 2003-12-4 |
| DOI | 10.1016/s0896-6273(03)00732-3 |
| PII | S0896627303007323 |
| PMID | 14659098 |
| MeSH | Aging / genetics Aging / physiology* Amnesia / genetics Amnesia / physiopathology Animals Avoidance Learning / physiology Drosophila / genetics Drosophila / physiology* Drosophila Proteins / genetics* Memory / physiology* Memory, Short-Term / physiology Mutation Neuropeptides / genetics* |
| IF | 14.415 |
| 引用数 | 95 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |