RRC ID 30438
Author Sone M, Suzuki E, Hoshino M, Hou D, Kuromi H, Fukata M, Kuroda S, Kaibuchi K, Nabeshima Y, Hama C.
Title Synaptic development is controlled in the periactive zones of Drosophila synapses.
Journal Development
Abstract A cell-adhesion molecule fasciclin 2 (FAS2), which is required for synaptic growth and still life (SIF), an activator of RAC, were found to localize in the surrounding region of the active zone, defining the periactive zone in Drosophila neuromuscular synapses. BetaPS integrin and discs large (DLG), both involved in synaptic development, also decorated the zone. However, shibire (SHI), the Drosophila dynamin that regulates endocytosis, was found in the distinct region. Mutant analyses showed that sif genetically interacted with Fas2 in synaptic growth and that the proper localization of SIF required FAS2, suggesting that they are components in related signaling pathways that locally function in the periactive zones. We propose that neurotransmission and synaptic growth are primarily regulated in segregated subcellular spaces, active zones and periactive zones, respectively.
Volume 127(19)
Pages 4157-68
Published 2000-10-1
DOI 10.1242/dev.127.19.4157
PMID 10976048
MeSH Animals Cell Adhesion Molecules, Neuronal / genetics Cell Adhesion Molecules, Neuronal / metabolism* Drosophila Drosophila Proteins* Dynamins GTP Phosphohydrolases Guanine Nucleotide Exchange Factors / genetics Guanine Nucleotide Exchange Factors / metabolism* Insect Proteins Integrins Neuromuscular Junction / growth & development* Neuromuscular Junction / ultrastructure Neurons / ultrastructure Receptors, Glutamate Signal Transduction Synaptic Membranes / ultrastructure Synaptic Transmission Tumor Suppressor Proteins* rac GTP-Binding Proteins / metabolism*
IF 5.611
Times Cited 96
WOS Category DEVELOPMENTAL BIOLOGY
Resource
Drosophila DGRC#109572 DGRC#109575