論文 - 詳細
| RRC ID | 30654 |
|---|---|
| 著者 | Yee C, Yang W, Hekimi S. |
| タイトル | The intrinsic apoptosis pathway mediates the pro-longevity response to mitochondrial ROS in C. elegans. |
| ジャーナル | Cell |
| Abstract |
The increased longevity of the C. elegans electron transport chain mutants isp-1 and nuo-6 is mediated by mitochondrial ROS (mtROS) signaling. Here we show that the mtROS signal is relayed by the conserved, mitochondria-associated, intrinsic apoptosis signaling pathway (CED-9/Bcl2, CED-4/Apaf1, and CED-3/Casp9) triggered by CED-13, an alternative BH3-only protein. Activation of the pathway by an elevation of mtROS does not affect apoptosis but protects from the consequences of mitochondrial dysfunction by triggering a unique pattern of gene expression that modulates stress sensitivity and promotes survival. In vertebrates, mtROS induce apoptosis through the intrinsic pathway to protect from severely damaged cells. Our observations in nematodes demonstrate that sensing of mtROS by the apoptotic pathway can, independently of apoptosis, elicit protective mechanisms that keep the organism alive under stressful conditions. This results in extended longevity when mtROS generation is inappropriately elevated. These findings clarify the relationships between mitochondria, ROS, apoptosis, and aging. |
| 巻・号 | 157(4) |
| ページ | 897-909 |
| 公開日 | 2014-5-8 |
| DOI | 10.1016/j.cell.2014.02.055 |
| PII | S0092-8674(14)00359-6 |
| PMID | 24813612 |
| PMC | PMC4454526 |
| MeSH | Adenosine Triphosphate / metabolism Aging Animals Apoptosis* Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Electron Transport / genetics Electron Transport Complex III / genetics Electron Transport Complex III / metabolism Longevity* Mitochondria / metabolism* Oxygen / metabolism Reactive Oxygen Species / metabolism* Signal Transduction Superoxide Dismutase / metabolism Transcriptome |
| IF | 38.637 |
| 引用数 | 197 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 65 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm783 tm760 |