論文 - 詳細
| RRC ID | 33174 |
|---|---|
| 著者 | Sarikaya DP, Extavour CG. |
| タイトル | The Hippo pathway regulates homeostatic growth of stem cell niche precursors in the Drosophila ovary. |
| ジャーナル | PLoS Genet |
| Abstract |
The Hippo pathway regulates organ size, stem cell proliferation and tumorigenesis in adult organs. Whether the Hippo pathway influences establishment of stem cell niche size to accommodate changes in organ size, however, has received little attention. Here, we ask whether Hippo signaling influences the number of stem cell niches that are established during development of the Drosophila larval ovary, and whether it interacts with the same or different effector signaling pathways in different cell types. We demonstrate that canonical Hippo signaling regulates autonomous proliferation of the soma, while a novel hippo-independent activity of Yorkie regulates autonomous proliferation of the germ line. Moreover, we demonstrate that Hippo signaling mediates non-autonomous proliferation signals between germ cells and somatic cells, and contributes to maintaining the correct proportion of these niche precursors. Finally, we show that the Hippo pathway interacts with different growth pathways in distinct somatic cell types, and interacts with EGFR and JAK/STAT pathways to regulate non-autonomous proliferation of germ cells. We thus provide evidence for novel roles of the Hippo pathway in establishing the precise balance of soma and germ line, the appropriate number of stem cell niches, and ultimately regulating adult female reproductive capacity. |
| 巻・号 | 11(2) |
| ページ | e1004962 |
| 公開日 | 2015-2-1 |
| DOI | 10.1371/journal.pgen.1004962 |
| PII | PGENETICS-D-14-02544 |
| PMID | 25643260 |
| PMC | PMC4333732 |
| MeSH | Animals Cell Differentiation / genetics* Cell Proliferation / genetics Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / growth & development ErbB Receptors / genetics ErbB Receptors / metabolism Female Germ Cells / cytology Germ Cells / growth & development* Homeostasis / genetics Intracellular Signaling Peptides and Proteins / genetics* Intracellular Signaling Peptides and Proteins / metabolism Ovary / growth & development Protein Serine-Threonine Kinases / genetics* Protein Serine-Threonine Kinases / metabolism RNA Interference Receptors, Invertebrate Peptide / genetics Receptors, Invertebrate Peptide / metabolism STAT Transcription Factors / genetics STAT Transcription Factors / metabolism Signal Transduction Stem Cell Niche / genetics* |
| IF | 5.175 |
| 引用数 | 29 |
| WOS 分野 | GENETICS & HEREDITY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | y w P{w[+mW.hs]=GawB}NP1624 (tj:GAL4 Kyoto Stock Center DGRC#104055) |