RRC ID 33632
Author Van Ryswyk L, Simonson L, Eisen JS.
Title The role of inab in axon morphology of an identified zebrafish motoneuron.
Journal PLoS One
Abstract The ability of an animal to move and to interact with its environment requires that motoneurons correctly innervate specific muscles. Although many genes that regulate motoneuron development have been identified, our understanding of motor axon branching remains incomplete. We used transcriptional expression profiling to identify potential candidate genes involved in development of zebrafish identified motoneurons. Here we focus on inab, an intermediate filament encoding gene dynamically expressed in a subset of motoneurons as well as in an identified interneuron. We show that inab is necessary for proper axon morphology of a specific motoneuron subtype.
Volume 9(2)
Pages e88631
Published 2014-1-1
DOI 10.1371/journal.pone.0088631
PII PONE-D-13-26382
PMID 24533123
PMC PMC3922942
MeSH Animals Axons / physiology* Cell Differentiation Gene Expression Profiling Gene Expression Regulation, Developmental Green Fluorescent Proteins / metabolism In Situ Hybridization, Fluorescence Interneurons / cytology Motor Neurons / cytology* Neurofilament Proteins / physiology* Oligonucleotide Array Sequence Analysis Spinal Cord / embryology* Spinal Cord / pathology Transcription, Genetic Zebrafish Zebrafish Proteins / physiology*
IF 2.74
Times Cited 2
Zebrafish Tg(chx10:GFP) Tg(vsx1:GFP)