論文 - 詳細
| RRC ID | 33632 |
|---|---|
| 著者 | Van Ryswyk L, Simonson L, Eisen JS. |
| タイトル | The role of inab in axon morphology of an identified zebrafish motoneuron. |
| ジャーナル | PLoS One |
| Abstract |
The ability of an animal to move and to interact with its environment requires that motoneurons correctly innervate specific muscles. Although many genes that regulate motoneuron development have been identified, our understanding of motor axon branching remains incomplete. We used transcriptional expression profiling to identify potential candidate genes involved in development of zebrafish identified motoneurons. Here we focus on inab, an intermediate filament encoding gene dynamically expressed in a subset of motoneurons as well as in an identified interneuron. We show that inab is necessary for proper axon morphology of a specific motoneuron subtype. |
| 巻・号 | 9(2) |
| ページ | e88631 |
| 公開日 | 2014-1-1 |
| DOI | 10.1371/journal.pone.0088631 |
| PII | PONE-D-13-26382 |
| PMID | 24533123 |
| PMC | PMC3922942 |
| MeSH | Animals Axons / physiology* Cell Differentiation Gene Expression Profiling Gene Expression Regulation, Developmental Green Fluorescent Proteins / metabolism In Situ Hybridization, Fluorescence Interneurons / cytology Motor Neurons / cytology* Neurofilament Proteins / physiology* Oligonucleotide Array Sequence Analysis Spinal Cord / embryology* Spinal Cord / pathology Transcription, Genetic Zebrafish Zebrafish Proteins / physiology* |
| IF | 2.74 |
| 引用数 | 2 |
| WOS 分野 | NEUROSCIENCES |
| リソース情報 | |
| ゼブラフィッシュ | Tg(chx10:GFP) Tg(vsx1:GFP) |