Reference - Detail
RRC ID | 33646 |
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Author | Lush ME, Piotrowski T. |
Title | ErbB expressing Schwann cells control lateral line progenitor cells via non-cell-autonomous regulation of Wnt/β-catenin. |
Journal | Elife |
Abstract |
Proper orchestration of quiescence and activation of progenitor cells is crucial during embryonic development and adult homeostasis. We took advantage of the zebrafish sensory lateral line to define niche-progenitor interactions to understand how integration of diverse signaling pathways spatially and temporally regulates the coordination of these processes. Our previous studies demonstrated that Schwann cells play a crucial role in negatively regulating lateral line progenitor proliferation. Here we demonstrate that ErbB/Neuregulin signaling is not only required for Schwann cell migration but that it plays a continued role in postmigratory Schwann cells. ErbB expressing Schwann cells inhibit lateral line progenitor proliferation and differentiation through non-cell-autonomous inhibition of Wnt/β-catenin signaling. Subsequent activation of Fgf signaling controls sensory organ differentiation, but not progenitor proliferation. In addition to the lateral line, these findings have important implications for understanding how niche-progenitor cells segregate interactions during development, and how they may go wrong in disease states. DOI: http://dx.doi.org/10.7554/eLife.01832.001. |
Volume | 3 |
Pages | e01832 |
Published | 2014-3-18 |
DOI | 10.7554/eLife.01832 |
PMID | 24642408 |
PMC | PMC3957165 |
MeSH | Animals Animals, Genetically Modified Cell Communication* / drug effects Cell Differentiation Cell Proliferation ErbB Receptors / antagonists & inhibitors ErbB Receptors / genetics ErbB Receptors / metabolism* Fibroblast Growth Factors / metabolism Gene Expression Regulation, Developmental Genotype Lateral Line System / cytology Lateral Line System / drug effects Lateral Line System / metabolism* Mutation Neural Stem Cells / drug effects Neural Stem Cells / metabolism* Neuregulins / metabolism Phenotype Protein Kinase Inhibitors / pharmacology Receptors, Notch / metabolism Schwann Cells / drug effects Schwann Cells / metabolism* Stem Cell Niche Time Factors Wnt Signaling Pathway* / drug effects Zebrafish / genetics Zebrafish / metabolism Zebrafish Proteins / genetics Zebrafish Proteins / metabolism* beta Catenin / genetics beta Catenin / metabolism* |
IF | 7.08 |
Times Cited | 33 |
WOS Category | BIOLOGY |
Resource | |
Zebrafish | Tg(6xTcf/LefBS-miniP:d2EGFP)/isi01 HGn39D |