論文 - 詳細
| RRC ID | 3397 |
|---|---|
| 著者 | Rhiner C, Gysi S, Fröhli E, Hengartner MO, Hajnal A. |
| タイトル | Syndecan regulates cell migration and axon guidance in C. elegans. |
| ジャーナル | Development |
| Abstract |
During nervous system development, axons that grow out simultaneously in the same extracellular environment are often sorted to different target destinations. As there is only a restricted set of guidance cues known, regulatory mechanisms are likely to play a crucial role in controlling cell migration and axonal pathfinding. Heparan sulfate proteoglycans (HSPGs) carry long chains of differentially modified sugar residues that have been proposed to encode specific information for nervous system development. Here, we show that the cell surface proteoglycan syndecan SDN-1 functions autonomously in neurons to control the neural migration and guidance choices of outgrowing axons. Epistasis analysis suggests that heparan sulfate (HS) attached to SDN-1 can regulate guidance signaling by the Slit/Robo pathway. Furthermore, SDN-1 acts in parallel with other HSPG core proteins whose HS side chains are modified by the C5-epimerase HSE-5, and/or the 2O-sulfotransferase HST-2, depending on the cellular context. Taken together, our experiments show that distinct HS modification patterns on SDN-1 are involved in regulating axon guidance and cell migration in C. elegans. |
| 巻・号 | 132(20) |
| ページ | 4621-33 |
| 公開日 | 2005-10-1 |
| DOI | 10.1242/dev.02042 |
| PII | dev.02042 |
| PMID | 16176946 |
| MeSH | Alleles Animals Axons / physiology* Body Patterning Caenorhabditis elegans / cytology* Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / metabolism Carbohydrate Epimerases / metabolism Cell Movement* Gene Expression Regulation, Developmental Genotype Membrane Glycoproteins / deficiency Membrane Glycoproteins / genetics Membrane Glycoproteins / metabolism* Mutation / genetics Nerve Tissue Proteins / metabolism Phenotype Proteoglycans / deficiency Proteoglycans / genetics Proteoglycans / metabolism* Receptors, Immunologic / metabolism Roundabout Proteins Signal Transduction Syndecans |
| IF | 5.611 |
| 引用数 | 80 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm472 |