Reference - Detail
| RRC ID | 3436 |
|---|---|
| Author | Hudson ML, Kinnunen T, Cinar HN, Chisholm AD. |
| Title | C. elegans Kallmann syndrome protein KAL-1 interacts with syndecan and glypican to regulate neuronal cell migrations. |
| Journal | Dev Biol |
| Abstract |
The anosmin-1 protein family regulates cell migration, axon guidance, and branching, by mechanisms that are not well understood. We show that the C. elegans anosmin-1 ortholog KAL-1 promotes migrations of ventral neuroblasts prior to epidermal enclosure. KAL-1 does not modulate FGF signaling in neuroblast migration and acts in parallel to other neuroblast migration pathways. Defects in heparan sulfate (HS) synthesis or in specific HS modifications disrupt neuroblast migrations and affect the KAL-1 pathway. KAL-1 binds the cell surface HS proteoglycans syndecan/SDN-1 and glypican/GPN-1. This interaction is mediated via HS side chains and requires specific HS modifications. SDN-1 and GPN-1 are expressed in ventral neuroblasts and have redundant roles in KAL-1-dependent neuroblast migrations. Our findings suggest that KAL-1 interacts with multiple HSPGs to promote cell migration. |
| Volume | 294(2) |
| Pages | 352-65 |
| Published | 2006-6-15 |
| DOI | 10.1016/j.ydbio.2006.02.036 |
| PII | S0012-1606(06)00135-7 |
| PMID | 16677626 |
| MeSH | Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / embryology Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Carbohydrate Sequence Cell Movement / physiology* Extracellular Matrix Proteins / genetics Extracellular Matrix Proteins / metabolism* Heparan Sulfate Proteoglycans / genetics Heparan Sulfate Proteoglycans / metabolism* Heparitin Sulfate / metabolism Humans Kallmann Syndrome Membrane Glycoproteins / genetics Membrane Glycoproteins / metabolism* Molecular Sequence Data Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism* Neurons / cytology Neurons / metabolism* Phenotype Proteoglycans / genetics Proteoglycans / metabolism* Recombinant Fusion Proteins / genetics Recombinant Fusion Proteins / metabolism Syndecans |
| IF | 2.896 |
| Times Cited | 49 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Resource | |
| C.elegans | tm472 tm595 tm588 |