RRC ID 36169
著者 Kanamori T, Yoshino J, Yasunaga K, Dairyo Y, Emoto K.
タイトル Local endocytosis triggers dendritic thinning and pruning in Drosophila sensory neurons.
ジャーナル Nat Commun
Abstract The refinement of neural circuits involves dendrite pruning, a process that removes inappropriate projections that are formed during development. In Drosophila sensory neurons, compartmentalized calcium (Ca(2+)) transients in dendrites act as spatiotemporal cues to trigger pruning, yet how neurons define the dendrites with Ca(2+) transients remains elusive. Here we report that local elevation of endocytic activity contributes to defining dendrites that generate Ca(2+) transients, triggering pruning. In vivo imaging of single dendrites reveals an increase of endocytosis in proximal dendrites that spatially and temporally correlates with dendrite thinning, an early step in pruning tightly coupled with compartmentalized Ca(2+) transients. Two GTPases, Rab5 and dynamin, are required for both the increased endocytic activity and compartmentalized Ca(2+) transients. Further genetic analyses suggest that local endocytosis in proximal dendrites functions cooperatively with global endocytosis-mediated protein degradation pathways to promote dendrite pruning.
巻・号 6
ページ 6515
公開日 2015-3-12
DOI 10.1038/ncomms7515
PII ncomms7515
PMID 25761586
MeSH Animals Animals, Genetically Modified Calcium / metabolism Calcium Signaling Cell Compartmentation Dendrites / metabolism* Dendrites / ultrastructure Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / genetics* Drosophila melanogaster / growth & development Drosophila melanogaster / metabolism Dynamins / genetics* Dynamins / metabolism Endocytosis / genetics* Endosomes / metabolism Gene Expression Regulation, Developmental Metamorphosis, Biological / genetics Molecular Imaging Neuronal Plasticity / genetics* Proteolysis Sensory Receptor Cells / metabolism Sensory Receptor Cells / ultrastructure rab5 GTP-Binding Proteins / genetics* rab5 GTP-Binding Proteins / metabolism
IF 12.121
引用数 23
WOS 分野 NEUROSCIENCES
リソース情報
ショウジョウバエ DGRC#106754