論文 - 詳細
| RRC ID | 3624 |
|---|---|
| 著者 | Penkner A, Tang L, Novatchkova M, Ladurner M, Fridkin A, Gruenbaum Y, Schweizer D, Loidl J, Jantsch V. |
| タイトル | The nuclear envelope protein Matefin/SUN-1 is required for homologous pairing in C. elegans meiosis. |
| ジャーナル | Dev Cell |
| Abstract |
We identify a highly specific mutation (jf18) in the Caenorhabditis elegans nuclear envelope protein matefin MTF-1/SUN-1 that provides direct evidence for active involvement of the nuclear envelope in homologous chromosome pairing in C. elegans meiosis. The reorganization of chromatin in early meiosis is disrupted in mtf-1/sun-1(jf18) gonads, concomitant with the absence of presynaptic homolog alignment. Synapsis is established precociously and nonhomologously. Wild-type leptotene/zygotene nuclei show patch-like aggregations of the ZYG-12 protein, which fail to develop in mtf-1/sun-1(jf18) mutants. These patches remarkably colocalize with a component of the cis-acting chromosomal pairing center (HIM-8) rather than the centrosome. Our data on this mtf-1/sun-1 allele challenge the previously postulated role of the centrosome/spindle organizing center in chromosome pairing, and clearly support a role for MTF-1/SUN-1 in meiotic chromosome reorganization and in homolog recognition, possibly by mediating local aggregation of the ZYG-12 protein in meiotic nuclei. |
| 巻・号 | 12(6) |
| ページ | 873-85 |
| 公開日 | 2007-6-1 |
| DOI | 10.1016/j.devcel.2007.05.004 |
| PII | S1534-5807(07)00199-2 |
| PMID | 17543861 |
| MeSH | Animals Animals, Genetically Modified Apoptosis Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Cell Nucleus / metabolism Chromosome Pairing* DNA Replication Gonads / metabolism In Situ Hybridization, Fluorescence Meiosis* Nuclear Envelope / metabolism* Protein Transport Receptors, Cytoplasmic and Nuclear / genetics Receptors, Cytoplasmic and Nuclear / physiology* Recombination, Genetic* |
| IF | 10.092 |
| 引用数 | 130 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1458 |