Reference - Detail
| RRC ID | 37639 |
|---|---|
| Author | Coulouarn C, Factor VM, Andersen JB, Durkin ME, Thorgeirsson SS. |
| Title | Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties. |
| Journal | Oncogene |
| Abstract |
Growing evidence indicates that microRNAs have a significant role in tumor development and may constitute robust biomarkers for cancer diagnosis and prognosis. In this study, we evaluated the clinical and functional relevance of microRNA-122 (miR-122) expression in human hepatocellular carcinoma (HCC). We report that miR-122 is specifically repressed in a subset of primary tumors that are characterized by poor prognosis. We further show that the loss of miR-122 expression in tumor cells segregates with specific gene expression profiles linked to cancer progression, namely the suppression of hepatic phenotype and the acquisition of invasive properties. We identify liver-enriched transcription factors as central regulatory molecules in the gene networks associated with loss of miR-122, and provide evidence suggesting that miR-122 is under the transcriptional control of HNF1A, HNF3A and HNF3B. We further show that loss of miR-122 results in an increase of cell migration and invasion and that restoration of miR-122 reverses this phenotype. In conclusion, miR-122 is a marker of hepatocyte-specific differentiation and an important determinant in the control of cell migration and invasion. From a clinical point of view, our study emphasizes miR-122 as a diagnostic and prognostic marker for HCC progression. |
| Volume | 28(40) |
| Pages | 3526-36 |
| Published | 2009-10-8 |
| DOI | 10.1038/onc.2009.211 |
| PII | onc2009211 |
| PMID | 19617899 |
| PMC | PMC3492882 |
| MeSH | Carcinoma, Hepatocellular / genetics* Carcinoma, Hepatocellular / mortality Carcinoma, Hepatocellular / pathology Cell Line, Tumor Gene Expression Profiling Humans Liver Neoplasms / genetics* Liver Neoplasms / mortality Liver Neoplasms / pathology MicroRNAs / analysis MicroRNAs / physiology* Neoplasm Invasiveness Neoplasm Metastasis Phenotype Prognosis |
| IF | 7.971 |
| Times Cited | 482 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY ONCOLOGY GENETICS & HEREDITY CELL BIOLOGY |
| Altmetric score |
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 83 |
| Altmetric score changes over past 6months | 3.0 |
| Resource | |
| Human and Animal Cells | HuH-6(RCB1367) |