論文 - 詳細
| RRC ID | 3863 |
|---|---|
| 著者 | Wu S, Murai S, Kataoka K, Miyagishi M. |
| タイトル | Yin Yang 1 induces transcriptional activity of p73 through cooperation with E2F1. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
The transcription factor p73 is a structural homologue of p53 and plays an important role in tumorigenesis, differentiation and development. However, the regulation of p73 pathway has not been wholly understood. Here we reported that YY1-silencing resulted in significant reductions in the activities of the p73 promoters and the endogenous p73 expression level, conversely, overexpression of YY1 could induce the activities of them. Furthermore, we showed that YY1 and E2F1 have synergistic effect on p73 promoter activity. The results of YY1-silencing and E2F1-silencing alone revealed that both factors are involved in the doxorubicin-induced activation of p73 promoter. Immunofluorescence staining and co-immunoprecipitation assays demonstrated that cooperation of YY1 and E2F1 is concomitant with physical interaction in nuclei. The results presented here suggested the cooperative transcriptional regulation of p73 by YY1 and E2F1, and might provide a new regulation mechanism by the YY1 network on tumorigenesis, differentiation and development. |
| 巻・号 | 365(1) |
| ページ | 75-81 |
| 公開日 | 2008-1-4 |
| DOI | 10.1016/j.bbrc.2007.10.145 |
| PII | S0006-291X(07)02304-2 |
| PMID | 17980704 |
| MeSH | Cell Line, Tumor Cells, Cultured DNA Damage DNA-Binding Proteins / genetics* DNA-Binding Proteins / metabolism E2F1 Transcription Factor / metabolism* Fluorescent Antibody Technique Humans Nuclear Proteins / genetics* Nuclear Proteins / metabolism Promoter Regions, Genetic Transcription, Genetic* Tumor Protein p73 Tumor Suppressor Proteins / genetics* Tumor Suppressor Proteins / metabolism YY1 Transcription Factor / metabolism* |
| IF | 2.985 |
| 引用数 | 22 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | Saos-2(RCB0428) |