| RRC ID |
3863
|
| 著者 |
Wu S, Murai S, Kataoka K, Miyagishi M.
|
| タイトル |
Yin Yang 1 induces transcriptional activity of p73 through cooperation with E2F1.
|
| ジャーナル |
Biochem Biophys Res Commun
|
| Abstract |
The transcription factor p73 is a structural homologue of p53 and plays an important role in tumorigenesis, differentiation and development. However, the regulation of p73 pathway has not been wholly understood. Here we reported that YY1-silencing resulted in significant reductions in the activities of the p73 promoters and the endogenous p73 expression level, conversely, overexpression of YY1 could induce the activities of them. Furthermore, we showed that YY1 and E2F1 have synergistic effect on p73 promoter activity. The results of YY1-silencing and E2F1-silencing alone revealed that both factors are involved in the doxorubicin-induced activation of p73 promoter. Immunofluorescence staining and co-immunoprecipitation assays demonstrated that cooperation of YY1 and E2F1 is concomitant with physical interaction in nuclei. The results presented here suggested the cooperative transcriptional regulation of p73 by YY1 and E2F1, and might provide a new regulation mechanism by the YY1 network on tumorigenesis, differentiation and development.
|
| 巻・号 |
365(1)
|
| ページ |
75-81
|
| 公開日 |
2008-1-4
|
| DOI |
10.1016/j.bbrc.2007.10.145
|
| PII |
S0006-291X(07)02304-2
|
| PMID |
17980704
|
| MeSH |
Cell Line, Tumor
Cells, Cultured
DNA Damage
DNA-Binding Proteins / genetics*
DNA-Binding Proteins / metabolism
E2F1 Transcription Factor / metabolism*
Fluorescent Antibody Technique
Humans
Nuclear Proteins / genetics*
Nuclear Proteins / metabolism
Promoter Regions, Genetic
Transcription, Genetic*
Tumor Protein p73
Tumor Suppressor Proteins / genetics*
Tumor Suppressor Proteins / metabolism
YY1 Transcription Factor / metabolism*
|
| IF |
2.985
|
| 引用数 |
22
|
|
WOS 分野
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| リソース情報 |
| ヒト・動物細胞 |
Saos-2(RCB0428) |
