| RRC ID |
3878
|
| Author |
Haga A, Funasaka T, Deyashiki Y, Raz A.
|
| Title |
Autocrine motility factor stimulates the invasiveness of malignant cells as well as up-regulation of matrix metalloproteinase-3 expression via a MAPK pathway.
|
| Journal |
FEBS Lett
|
| Abstract |
The autocrine motility factor (AMF) is a multifunctional protein that is involved in tumor progression including enhanced invasiveness via induction of matrix metalloproteinase-3 (MMP3). The increase in MMP3 was found in an AMF-high production tumor cell line, and c-Jun, c-Fos and mitogen-activated protein kinases (MAPKs) were also highly phosphorylated compared with the parent line. AMF stimulation induced the rapid phosphorylation of the cellular MAPK cascade and MMP3 secretion, which was blocked using a specific MAPK inhibitor. Results of this study suggest that AMF stimulation stimulates MMP3 expression via a MAPK signaling pathway.
|
| Volume |
582(13)
|
| Pages |
1877-82
|
| Published |
2008-6-11
|
| DOI |
10.1016/j.febslet.2008.05.005
|
| PII |
S0014-5793(08)00402-X
|
| PMID |
18485900
|
| PMC |
PMC3788612
|
| MeSH |
Cell Line, Tumor
Cell Movement
Enzyme Activation
Glucose-6-Phosphate Isomerase / metabolism*
Glucose-6-Phosphate Isomerase / pharmacology
Humans
MAP Kinase Kinase 4 / antagonists & inhibitors
MAP Kinase Kinase 4 / metabolism*
Matrix Metalloproteinase 3 / genetics
Matrix Metalloproteinase 3 / metabolism*
Mitogen-Activated Protein Kinases / metabolism
Neoplasm Invasiveness*
Phosphorylation
Proto-Oncogene Proteins c-fos / metabolism
Receptors, Autocrine Motility Factor
Receptors, Cytokine / genetics
Receptors, Cytokine / metabolism
Ubiquitin-Protein Ligases / genetics
Ubiquitin-Protein Ligases / metabolism
Up-Regulation
|
| IF |
3.057
|
| Times Cited |
10
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Human and Animal Cells |
THP-1(RCB1189) |
