論文 - 詳細
| RRC ID | 38793 |
|---|---|
| 著者 | Koseki T, Yamato K, Krajewski S, Reed JC, Tsujimoto Y, Nishihara T. |
| タイトル | Activin A-induced apoptosis is suppressed by BCL-2. |
| ジャーナル | FEBS Lett |
| Abstract |
Activin A, a member of TGF beta superfamily has various activities including induction of apoptosis in mammalian cells. However, it remains unknown how activin A induces cell death. To clarify this, we investigated the expression of BCL-2 and BAX, and the effect of BCL-2 overexpression on activin A-induced apoptosis in B cell hybridoma cell lines. The activin A-sensitive cell lines expressed BAX but not BCL-2 and that activin A did not increase BAX levels. Overexpression of human BCL-2 suppressed activin A-induced apoptosis in these cells. Thus, activin A has been shown to induce apoptosis by a BCL-2-inhibitable mechanism without activating BAX. |
| 巻・号 | 376(3) |
| ページ | 247-50 |
| 公開日 | 1995-12-4 |
| DOI | 10.1016/0014-5793(95)01290-7 |
| PII | 0014-5793(95)01290-7 |
| PMID | 7498552 |
| MeSH | Activins Animals Apoptosis* Cells, Cultured DNA / metabolism Humans Hybridomas Inhibins / physiology* Mice Proto-Oncogene Proteins / physiology* Proto-Oncogene Proteins c-bcl-2 bcl-2-Associated X Protein |
| IF | 3.057 |
| 引用数 | 24 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | M1(RCB0169) U-937 DE-4(RCB0435) |