論文 - 詳細
| RRC ID | 41336 |
|---|---|
| 著者 | Wu Q, Sun Y, Wang J, Lin X, Wang Y, Pegg LE, Fütterer A, Pfeffer K, Fu YX. |
| タイトル | Signal via lymphotoxin-beta R on bone marrow stromal cells is required for an early checkpoint of NK cell development. |
| ジャーナル | J Immunol |
| Abstract |
NK cells play an important role in the immune system but the cellular and molecular requirements for their early development are poorly understood. Lymphotoxin-alpha (LTalpha)(-/-) and LTbetaR(-/-) mice show a severe systemic reduction of NK cells, which provides an excellent model to study NK cell development. In this study, we show that the bone marrow (BM) or fetal liver cells from LTalpha(-/-) or LTbetaR(-/-) mice efficiently develop into mature NK cells in the presence of stromal cells from wild-type mice but not from LTalpha(-/-) or LTbetaR(-/-) mice. Direct activation of LTbetaR-expressing BM stromal cells is shown to promote to early NK cell development in vitro. Furthermore, the blockade of the interaction between LT and LTbetaR in adult wild-type mice by administration of LTbetaR-Ig impairs the development of NK cells in vivo. Together, these results indicate that the signal via LTbetaR on BM stromal cells by membrane LT is an important pathway for early NK cell development. |
| 巻・号 | 166(3) |
| ページ | 1684-9 |
| 公開日 | 2001-2-1 |
| DOI | 10.4049/jimmunol.166.3.1684 |
| PMID | 11160211 |
| MeSH | Adoptive Transfer Animals Bone Marrow Cells / cytology Bone Marrow Cells / immunology* Bone Marrow Cells / metabolism Bone Marrow Transplantation Cell Differentiation / genetics Cell Differentiation / immunology Cell Line Cells, Cultured Hematopoietic Stem Cells / cytology* Hematopoietic Stem Cells / immunology* Hematopoietic Stem Cells / pathology Homeostasis / immunology Killer Cells, Natural / cytology* Killer Cells, Natural / immunology* Killer Cells, Natural / metabolism Killer Cells, Natural / pathology Lymphocyte Activation / genetics Lymphocyte Count Lymphoid Tissue / immunology Lymphoid Tissue / pathology Lymphopenia / genetics Lymphopenia / immunology Lymphopenia / therapy Lymphotoxin beta Receptor Lymphotoxin-alpha / genetics Lymphotoxin-alpha / metabolism* Lymphotoxin-beta Membrane Proteins / metabolism* Mice Mice, Inbred C57BL Mice, Knockout Receptors, Tumor Necrosis Factor / deficiency Receptors, Tumor Necrosis Factor / genetics Receptors, Tumor Necrosis Factor / physiology* Signal Transduction / genetics Signal Transduction / immunology* Stromal Cells / immunology Stromal Cells / metabolism T-Lymphocyte Subsets / pathology |
| IF | 4.886 |
| 引用数 | 51 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | OP9(RCB1124) |