Reference - Detail
| RRC ID | 41990 |
|---|---|
| Author | Kobori M, Yang Z, Gong D, Heissmeyer V, Zhu H, Jung YK, Gakidis MA, Rao A, Sekine T, Ikegami F, Yuan C, Yuan J. |
| Title | Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibiting the IKK complex. |
| Journal | Cell Death Differ |
| Abstract |
Caspase-11 is a key regulator of proinflammatory cytokine IL-1beta maturation and pathological apoptosis. Caspase-11 is not expressed in most tissues under normal condition, but highly inducible upon pathological stimulation such as in the presence of lipopolysaccharide (LPS). Here, we describe the identification and characterization of wedelolactone, a natural compound that inhibits LPS-induced caspase-11 expression in cultured cells by inhibiting NF-kappaB-mediated transcription. We demonstrate that wedelolactone is an inhibitor of IKK, a kinase critical for activation of NF-kappaB by mediating phosphorylation and degradation of IkappaBalpha. |
| Volume | 11(1) |
| Pages | 123-30 |
| Published | 2004-1-1 |
| DOI | 10.1038/sj.cdd.4401325 |
| PII | 4401325 |
| PMID | 14526390 |
| MeSH | Animals Biomarkers Caspases / biosynthesis* Caspases / drug effects Caspases, Initiator Cells, Cultured Coumarins / chemical synthesis Coumarins / chemistry Coumarins / isolation & purification Coumarins / pharmacology* Eclipta / chemistry Gene Expression Regulation, Enzymologic / drug effects Humans I-kappa B Kinase I-kappa B Proteins / metabolism Lipopolysaccharides / pharmacology Mice Mice, Inbred BALB C NF-kappa B / metabolism Protein Serine-Threonine Kinases / antagonists & inhibitors* Protein Serine-Threonine Kinases / metabolism Transcription Factors / metabolism Tumor Suppressor Protein p53 / metabolism |
| IF | 10.717 |
| Times Cited | 150 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Resource | |
| Human and Animal Cells | HeLa(RCB0007) |