RRC ID 4308
Author Tsunozaki M, Chalasani SH, Bargmann CI.
Title A behavioral switch: cGMP and PKC signaling in olfactory neurons reverses odor preference in C. elegans.
Journal Neuron
Abstract Innate chemosensory preferences are often encoded by sensory neurons that are specialized for attractive or avoidance behaviors. Here, we show that one olfactory neuron in Caenorhabditis elegans, AWC(ON), has the potential to direct both attraction and repulsion. Attraction, the typical AWC(ON) behavior, requires a receptor-like guanylate cyclase GCY-28 that acts in adults and localizes to AWC(ON) axons. gcy-28 mutants avoid AWC(ON)-sensed odors; they have normal odor-evoked calcium responses in AWC(ON) but reversed turning biases in odor gradients. In addition to gcy-28, a diacylglycerol/protein kinase C pathway that regulates neurotransmission switches AWC(ON) odor preferences. A behavioral switch in AWC(ON) may be part of normal olfactory plasticity, as odor conditioning can induce odor avoidance in wild-type animals. Genetic interactions, acute rescue, and calcium imaging suggest that the behavioral reversal results from presynaptic changes in AWC(ON). These results suggest that alternative modes of neurotransmission can couple one sensory neuron to opposite behavioral outputs.
Volume 59(6)
Pages 959-71
Published 2008-9-25
DOI 10.1016/j.neuron.2008.07.038
PII S0896-6273(08)00669-7
PMID 18817734
PMC PMC2586605
MeSH Animals Appetitive Behavior / physiology Avoidance Learning / physiology* Behavior, Animal / physiology Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Chemotaxis / genetics Chemotaxis / physiology Guanylate Cyclase / genetics Guanylate Cyclase / metabolism* Nerve Tissue Proteins / genetics Neurons, Afferent / metabolism* Protein-Serine-Threonine Kinases / genetics Protein-Serine-Threonine Kinases / metabolism Signal Transduction / physiology Smell / physiology*
IF 14.403
Times Cited 65
C.elegans tm2411