論文 - 詳細
| RRC ID | 43162 |
|---|---|
| 著者 | Miyazono A, Yamada A, Morimura N, Takami M, Suzuki D, Kobayashi M, Tezuka K, Yamamoto M, Kamijo R. |
| タイトル | TGF-beta suppresses POEM expression through ERK1/2 and JNK in osteoblasts. |
| ジャーナル | FEBS Lett |
| Abstract |
POEM, also called nephronectin, is an extracellular matrix protein that is considered to play a critical role as an adhesion molecule in the development and functioning of various tissues, such as kidneys and bones. In the present study, we examined the molecular mechanism of POEM gene expression, and found that transforming growth factor-beta (TGF-beta) strongly inhibited POEM expression in the mouse osteoblastic cell line, MC3T3-E1. TGF-beta-induced decrease of POEM expression occurred in both time- and dose-dependent manners through the activation of TGF-beta receptor I and extracellular signal-regulated kinase/c-Jun N-terminal kinase pathways. |
| 巻・号 | 581(27) |
| ページ | 5321-6 |
| 公開日 | 2007-11-13 |
| DOI | 10.1016/j.febslet.2007.10.021 |
| PII | S0014-5793(07)01081-2 |
| PMID | 17977532 |
| MeSH | 3T3 Cells Animals Base Sequence Bone Morphogenetic Protein 2 Bone Morphogenetic Proteins / pharmacology Cells, Cultured Down-Regulation / drug effects Extracellular Matrix Proteins / genetics* JNK Mitogen-Activated Protein Kinases / metabolism MAP Kinase Signaling System / drug effects* Mice Mitogen-Activated Protein Kinase 1 / metabolism Mitogen-Activated Protein Kinase 3 / metabolism Models, Biological Osteoblasts / drug effects* Osteoblasts / metabolism* Protein Serine-Threonine Kinases / metabolism RNA, Messenger / genetics RNA, Messenger / metabolism Receptor, Transforming Growth Factor-beta Type I Receptors, Transforming Growth Factor beta / metabolism Recombinant Proteins / pharmacology Transforming Growth Factor beta / pharmacology Transforming Growth Factor beta1 / pharmacology* |
| IF | 3.057 |
| 引用数 | 17 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | MC3T3-E1(RCB1126) |