論文 - 詳細
| RRC ID | 44370 |
|---|---|
| 著者 | Okui G, Tobiume K, Rizqiawan A, Yamamoto K, Shigeishi H, Ono S, Higashikawa K, Kamata N. |
| タイトル | AKT primes snail-induced EMT concomitantly with the collective migration of squamous cell carcinoma cells. |
| ジャーナル | J Cell Biochem |
| Abstract |
In this study, we found that wounding of a confluent monolayer of squamous cell carcinoma (SCC) cells induced epithelial-mesenchymal transition (EMT) specifically at the edge of the wound. This process required the combined stimulation of TGFβ, TNFα, and PDGF-D. Such a combined cytokine treatment of confluent monolayers of the cells upregulated the expression levels of Snail and Slug via PI3K. The PI3K downstream effector, AKT, was dispensable for the upregulation of Snail and Slug, but essential for enabling EMT in response to upregulation of Snail and Slug. |
| 巻・号 | 114(9) |
| ページ | 2039-49 |
| 公開日 | 2013-9-1 |
| DOI | 10.1002/jcb.24545 |
| PMID | 23553960 |
| MeSH | Carcinoma, Squamous Cell / metabolism* Cell Line Cell Movement / genetics Cell Movement / physiology Epithelial-Mesenchymal Transition / genetics Epithelial-Mesenchymal Transition / physiology* Humans Immunoblotting Immunohistochemistry Lymphokines / metabolism Phosphatidylinositol 3-Kinases / genetics Phosphatidylinositol 3-Kinases / metabolism Platelet-Derived Growth Factor / metabolism Proto-Oncogene Proteins c-akt / genetics Proto-Oncogene Proteins c-akt / metabolism* Snail Family Transcription Factors Transcription Factors / metabolism* Transforming Growth Factor beta / metabolism Tumor Necrosis Factor-alpha / metabolism Wound Healing / genetics Wound Healing / physiology |
| IF | 4.237 |
| 引用数 | 14 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| ヒト・動物細胞 | |