Reference - Detail
| RRC ID | 44595 |
|---|---|
| Author | Shibuta T, Honda E, Shiotsu H, Tanaka Y, Vellasamy S, Shiratsuchi M, Umemura T. |
| Title | Imatinib induces demethylation of miR-203 gene: an epigenetic mechanism of anti-tumor effect of imatinib. |
| Journal | Leuk Res |
| Abstract |
MicroRNA (miRNA) is an important regulator of cellular proliferation, differentiation and death. Leukemia-specific signature of miRNAs suggests that epigenetic dysregulation of miRNAs is important for leukemogenesis. We focused on the role of DNA methylation of miR-203 which targets BCR-ABL1 mRNA. The microarray analysis showed that 48 miRNAs of CpG-rich 212 miRNAs were upregulated over 2-fold after imatinib treatment. Imatinib induced the demethylation of the miR-203 promoter region, resulting in low expression of targeted BCR-ABL1 gene, and loss of proliferation of leukemic cells. In conclusion, demethylation of miR-203 is one of the molecular mechanisms of imatinib-induced inhibition of BCR-ABL1-positive leukemic cells. |
| Volume | 37(10) |
| Pages | 1278-86 |
| Published | 2013-10-1 |
| DOI | 10.1016/j.leukres.2013.07.019 |
| PII | S0145-2126(13)00246-4 |
| PMID | 23953880 |
| MeSH | Antineoplastic Agents / pharmacology* Benzamides / pharmacology* Cell Line, Tumor CpG Islands DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases / genetics DNA (Cytosine-5-)-Methyltransferases / metabolism DNA Methylation / drug effects* Epigenesis, Genetic / drug effects* Fusion Proteins, bcr-abl / genetics Fusion Proteins, bcr-abl / metabolism Gene Expression Profiling Gene Expression Regulation, Leukemic / drug effects Humans Imatinib Mesylate Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism MicroRNAs / genetics* MicroRNAs / metabolism Piperazines / pharmacology* Promoter Regions, Genetic Protein Kinase Inhibitors / pharmacology* Pyrimidines / pharmacology* RNA, Messenger / genetics RNA, Messenger / metabolism |
| IF | 2.214 |
| Times Cited | 27 |
| WOS Category | ONCOLOGY HEMATOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Human and Animal Cells | KU812(RCB0495) |