RRC ID 45675
著者 Alvares SM, Mayberry GA, Joyner EY, Lakowski B, Ahmed S.
タイトル H3K4 demethylase activities repress proliferative and postmitotic aging.
ジャーナル Aging Cell
Abstract Homeostasis of postmitotic and proliferating cells is maintained by pathways that repress stress. We found that the Caenorhabditis elegans histone 3 lysine 4 (H3K4) demethylases RBR-2 and SPR-5 promoted postmitotic longevity of stress-resistant daf-2 adults, altered pools of methylated H3K4, and promoted silencing of some daf-2 target genes. In addition, RBR-2 and SPR-5 were required for germ cell immortality at a high temperature. Transgenerational proliferative aging was enhanced for spr-5; rbr-2 double mutants, suggesting that these histone demethylases may function sequentially to promote germ cell immortality by targeting distinct H3K4 methyl marks. RBR-2 did not play a comparable role in the maintenance of quiescent germ cells in dauer larvae, implying that it represses stress that occurs as a consequence of germ cell proliferation, rather than stress that accumulates in nondividing cells. We propose that H3K4 demethylase activities promote the maintenance of chromatin states during stressful growth conditions, thereby repressing postmitotic aging of somatic cells as well as proliferative aging of germ cells.
巻・号 13(2)
ページ 245-53
公開日 2014-4-1
DOI 10.1111/acel.12166
PMID 24134677
PMC PMC4020274
MeSH Animals Caenorhabditis elegans / cytology* Caenorhabditis elegans / enzymology Caenorhabditis elegans Proteins / metabolism* Cell Proliferation Cellular Senescence* Fertility Germ Cells / cytology Germ Cells / metabolism Heterozygote Histone Demethylases / metabolism* Histones / metabolism* Longevity Lysine / metabolism* Methylation Mitosis* Mutation / genetics Phenotype Retinoblastoma-Binding Protein 2 / metabolism* Temperature
IF 7.238
引用数 20
WOS 分野 GERIATRICS & GERONTOLOGY CELL BIOLOGY
リソース情報
線虫 tm1231