Reference - Detail
| RRC ID | 45737 |
|---|---|
| Author | Guo M, Wu TH, Song YX, Ge MH, Su CM, Niu WP, Li LL, Xu ZJ, Ge CL, Al-Mhanawi MT, Wu SP, Wu ZX. |
| Title | Reciprocal inhibition between sensory ASH and ASI neurons modulates nociception and avoidance in Caenorhabditis elegans. |
| Journal | Nat Commun |
| Abstract |
Sensory modulation is essential for animal sensations, behaviours and survival. Peripheral modulations of nociceptive sensations and aversive behaviours are poorly understood. Here we identify a biased cross-inhibitory neural circuit between ASH and ASI sensory neurons. This inhibition is essential to drive normal adaptive avoidance of a CuSO4 (Cu(2+)) challenge in Caenorhabditis elegans. In the circuit, ASHs respond to Cu(2+) robustly and suppress ASIs via electro-synaptically exciting octopaminergic RIC interneurons, which release octopamine (OA), and neuroendocrinally inhibit ASI by acting on the SER-3 receptor. In addition, ASIs sense Cu(2+) and permit a rapid onset of Cu(2+)-evoked responses in Cu(2+)-sensitive ADF neurons via neuropeptides possibly, to inhibit ASHs. ADFs function as interneurons to mediate ASI inhibition of ASHs by releasing serotonin (5-HT) that binds with the SER-5 receptor on ASHs. This elaborate modulation among sensory neurons via reciprocal inhibition fine-tunes the nociception and avoidance behaviour. |
| Volume | 6 |
| Pages | 5655 |
| Published | 2015-1-13 |
| DOI | 10.1038/ncomms6655 |
| PII | ncomms6655 |
| PMID | 25585042 |
| MeSH | Animals Avoidance Learning* Behavior, Animal Biomechanical Phenomena Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism Calcium / metabolism Copper / chemistry Copper Sulfate / chemistry Genotype Interneurons / physiology* Microscopy, Confocal Mutation Neurons / physiology* Neuropeptides / chemistry Nociception / physiology* Nociceptors / metabolism Octopamine / chemistry Sensory Receptor Cells / physiology Serotonin / chemistry Signal Transduction / physiology* |
| IF | 12.121 |
| Times Cited | 28 |
| WOS Category | NEUROSCIENCES |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 3 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm2647 tm1377 tm1815 |