RRC ID 45925
Author Barros AG, Bridi JC, de Souza BR, de Castro Júnior C, de Lima Torres KC, Malard L, Jorio A, de Miranda DM, Ashrafi K, Romano-Silva MA.
Title Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans.
Journal PLoS One
Abstract The regulation of energy balance involves an intricate interplay between neural mechanisms that respond to internal and external cues of energy demand and food availability. Compelling data have implicated the neurotransmitter dopamine as an important part of body weight regulation. However, the precise mechanisms through which dopamine regulates energy homeostasis remain poorly understood. Here, we investigate mechanisms through which dopamine modulates energy storage. We showed that dopamine signaling regulates fat reservoirs in Caenorhabditis elegans. We found that the fat reducing effects of dopamine were dependent on dopaminergic receptors and a set of fat oxidation enzymes. Our findings reveal an ancient role for dopaminergic regulation of fat and suggest that dopamine signaling elicits this outcome through cascades that ultimately mobilize peripheral fat depots.
Volume 9(1)
Pages e85874
Published 2014-1-1
DOI 10.1371/journal.pone.0085874
PII PONE-D-13-04162
PMID 24465759
PMC PMC3899111
MeSH Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Dopamine / metabolism* Dopamine / pharmacology Dopamine Agents / metabolism Dopamine Agents / pharmacology Energy Metabolism / drug effects Fats / metabolism* Gene Expression Homeostasis / drug effects Lipid Metabolism / drug effects Microscopy, Fluorescence Mutation Oxidation-Reduction / drug effects RNA Interference Receptors, Dopamine / genetics Receptors, Dopamine / metabolism Reverse Transcriptase Polymerase Chain Reaction Serotonin / pharmacology Serotonin Receptor Agonists / pharmacology Signal Transduction* Time Factors
IF 2.74
Times Cited 8
C.elegans tm351 tm1037