RRC ID 46021
著者 Kunitomo H, Sato H, Iwata R, Satoh Y, Ohno H, Yamada K, Iino Y.
タイトル Concentration memory-dependent synaptic plasticity of a taste circuit regulates salt concentration chemotaxis in Caenorhabditis elegans.
ジャーナル Nat Commun
Abstract It is poorly understood how sensory systems memorize the intensity of sensory stimulus, compare it with a newly sensed stimulus, and regulate the orientation behaviour based on the memory. Here we report that Caenorhabditis elegans memorizes the environmental salt concentration during cultivation and exhibits a strong behavioural preference for this concentration. The right-sided amphid gustatory neuron known as ASER, senses decreases in salt concentration, and this information is transmitted to the postsynaptic AIB interneurons only in the salt concentration range lower than the cultivation concentration. In this range, animals migrate towards higher concentration by promoting turning behaviour upon decreases in salt concentration. These observations provide a mechanism for adjusting the orientation behaviour based on the memory of sensory stimulus using a simple neural circuit.
巻・号 4
ページ 2210
公開日 2013-1-1
DOI 10.1038/ncomms3210
PII ncomms3210
PMID 23887678
MeSH Animals Behavior, Animal Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Chemotaxis / physiology Gene Expression Regulation Interneurons / cytology Interneurons / physiology Memory / physiology Neuronal Plasticity / physiology Orientation / physiology Sensory Receptor Cells / cytology Sensory Receptor Cells / physiology Signal Transduction Sodium Chloride / metabolism Synapses / physiology Taste / physiology
IF 12.121
引用数 38
WOS 分野 NEUROSCIENCES
リソース情報
線虫 tm753 tm2364