RRC ID 46065
著者 Liu T, Cai D.
タイトル Counterbalance between BAG and URX neurons via guanylate cyclases controls lifespan homeostasis in C. elegans.
ジャーナル EMBO J
Abstract Lifespan of C. elegans is affected by the nervous system; however, the underlying neural integration still remains unclear. In this work, we targeted an antagonistic neural system consisting of low-oxygen sensing BAG neurons and high-oxygen sensing URX neurons. While ablation of BAG neurons increases lifespan of C. elegans, ablation of URX neurons decreases lifespan. Genetic analysis revealed that BAG and URX neurons counterbalance each other via different guanylate cyclases (GCYs) to control lifespan balance. Lifespan-modulating effects of GCYs in these neurons are independent of the actions from insulin/IGF-1 signalling, germline signalling, sensory perception, or dietary restriction. Given the known gas-sensing property of these neurons, we profiled that lifespan of C. elegans is promoted under moderately low oxygen (4-12%) or moderately high carbon dioxide (5%) but inhibited under high-level oxygen (40%); however, these pro-longevity and anti-longevity effects are counteracted, respectively, by BAG and URX neurons via different GCYs. In conclusion, BAG and URX neurons work as a neural-regulatory system to counterbalance each other via different GCYs to control lifespan homeostasis.
巻・号 32(11)
ページ 1529-42
公開日 2013-5-29
DOI 10.1038/emboj.2013.75
PII emboj201375
PMID 23584532
PMC PMC3671255
MeSH Animals Caenorhabditis elegans / enzymology Caenorhabditis elegans / genetics* Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics* Caenorhabditis elegans Proteins / metabolism Carbon Dioxide / physiology Cell Survival Gene Expression Regulation, Enzymologic Guanylate Cyclase / genetics* Guanylate Cyclase / metabolism Homeostasis Humans Longevity / genetics* Models, Biological Mutation Neurons / enzymology Neurons / physiology* Organ Specificity Organisms, Genetically Modified Oxygen / physiology Signal Transduction / physiology
IF 9.889
引用数 14
WOS 分野 BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY
リソース情報
線虫 tm2816