RRC ID 46095
Author Gallo M, Park D, Riddle DL.
Title Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway.
Journal Mech Ageing Dev
Abstract The Caenorhabditis elegans misc-1 gene encodes a mitochondrial carrier with a role in oxidative stress response. The knock-out mutant has no lifespan phenotype and fails to upregulate the gei-7-mediated glyoxylate shunt, an extra-mitochondrial pathway of energy production. We show that gei-7 is required for the longevity of the mitochondrial mutant clk-1. Our data suggest that only mitochondrial mutants that upregulate gei-7 can achieve longevity.
Volume 132(10)
Pages 515-8
Published 2011-10-1
DOI 10.1016/j.mad.2011.08.004
PII S0047-6374(11)00123-0
PMID 21884719
MeSH Animals Anion Transport Proteins / genetics Anion Transport Proteins / metabolism Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Energy Metabolism / genetics Gene Knockdown Techniques Gene Knockout Techniques Genes, Helminth* Genes, Mitochondrial* Longevity / genetics* Longevity / physiology* Mitochondria / genetics Mitochondria / metabolism Mitochondrial Proteins Mutation Oxidative Stress Reactive Oxygen Species / metabolism
IF 4.304
Times Cited 19
C.elegans NA