Reference - Detail
RRC ID | 46095 |
---|---|
Author | Gallo M, Park D, Riddle DL. |
Title | Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway. |
Journal | Mech Ageing Dev |
Abstract |
The Caenorhabditis elegans misc-1 gene encodes a mitochondrial carrier with a role in oxidative stress response. The knock-out mutant has no lifespan phenotype and fails to upregulate the gei-7-mediated glyoxylate shunt, an extra-mitochondrial pathway of energy production. We show that gei-7 is required for the longevity of the mitochondrial mutant clk-1. Our data suggest that only mitochondrial mutants that upregulate gei-7 can achieve longevity. |
Volume | 132(10) |
Pages | 515-8 |
Published | 2011-10-1 |
DOI | 10.1016/j.mad.2011.08.004 |
PII | S0047-6374(11)00123-0 |
PMID | 21884719 |
MeSH | Animals Anion Transport Proteins / genetics Anion Transport Proteins / metabolism Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Energy Metabolism / genetics Gene Knockdown Techniques Gene Knockout Techniques Genes, Helminth* Genes, Mitochondrial* Longevity / genetics* Longevity / physiology* Mitochondria / genetics Mitochondria / metabolism Mitochondrial Proteins Mutation Oxidative Stress Reactive Oxygen Species / metabolism |
IF | 4.304 |
Times Cited | 19 |
WOS Category | GERIATRICS & GERONTOLOGY CELL BIOLOGY |
Resource | |
C.elegans | NA |