論文 - 詳細
| RRC ID | 46095 |
|---|---|
| 著者 | Gallo M, Park D, Riddle DL. |
| タイトル | Increased longevity of some C. elegans mitochondrial mutants explained by activation of an alternative energy-producing pathway. |
| ジャーナル | Mech Ageing Dev |
| Abstract |
The Caenorhabditis elegans misc-1 gene encodes a mitochondrial carrier with a role in oxidative stress response. The knock-out mutant has no lifespan phenotype and fails to upregulate the gei-7-mediated glyoxylate shunt, an extra-mitochondrial pathway of energy production. We show that gei-7 is required for the longevity of the mitochondrial mutant clk-1. Our data suggest that only mitochondrial mutants that upregulate gei-7 can achieve longevity. |
| 巻・号 | 132(10) |
| ページ | 515-8 |
| 公開日 | 2011-10-1 |
| DOI | 10.1016/j.mad.2011.08.004 |
| PII | S0047-6374(11)00123-0 |
| PMID | 21884719 |
| MeSH | Animals Anion Transport Proteins / genetics Anion Transport Proteins / metabolism Caenorhabditis elegans / genetics* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Energy Metabolism / genetics Gene Knockdown Techniques Gene Knockout Techniques Genes, Helminth* Genes, Mitochondrial* Longevity / genetics* Longevity / physiology* Mitochondria / genetics Mitochondria / metabolism Mitochondrial Proteins Mutation Oxidative Stress Reactive Oxygen Species / metabolism |
| IF | 4.304 |
| 引用数 | 19 |
| WOS 分野 | GERIATRICS & GERONTOLOGY CELL BIOLOGY |
| リソース情報 | |
| 線虫 | NA |