Reference - Detail
RRC ID | 46120 |
---|---|
Author | O'Rourke EJ, Ruvkun G. |
Title | MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. |
Journal | Nat Cell Biol |
Abstract |
Fat is stored or mobilized according to food availability. Malfunction of the mechanisms that ensure this coordination underlie metabolic diseases in humans. In mammals, lysosomal and autophagic function is required for normal fat storage and mobilization in the presence or absence of food. Autophagy is tightly linked to nutrients. However, if and how lysosomal lipolysis is coupled to nutritional status remains to be determined. Here we identify MXL-3 and HLH-30 (TFEB orthologue) [corrected] as transcriptional switches coupling lysosomal lipolysis and autophagy to nutrient availability and controlling fat storage and ageing in Caenorhabditis elegans. Transcriptional coupling of lysosomal lipolysis and autophagy to nutrients is also observed in mammals. Thus, MXL-3 and HLH-30 orchestrate an adaptive and conserved cellular response to nutritional status and regulate lifespan. |
Volume | 15(6) |
Pages | 668-76 |
Published | 2013-6-1 |
DOI | 10.1038/ncb2741 |
PII | ncb2741 |
PMID | 23604316 |
PMC | PMC3723461 |
MeSH | Aging / genetics Aging / metabolism Animals Autophagy / physiology* Basic Helix-Loop-Helix Transcription Factors / genetics Basic Helix-Loop-Helix Transcription Factors / metabolism* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Fasting Lipase / genetics Lipase / metabolism Lipolysis / physiology* Lysosomes / metabolism Trans-Activators / metabolism Transcription Factors |
IF | 20.042 |
Times Cited | 150 |
WOS Category | CELL BIOLOGY |
Resource | |
C.elegans | tm1954 tm4498 tm2580 tm1978 |