Reference - Detail
| RRC ID | 46224 |
|---|---|
| Author | Wang H, Lu Q, Cheng S, Wang X, Zhang H. |
| Title | Autophagy activity contributes to programmed cell death in Caenorhabditis elegans. |
| Journal | Autophagy |
| Abstract |
The physiological relationship between autophagy and programmed cell death during C. elegans development is poorly understood. In C. elegans, 131 somatic cells and a large number of germline cells undergo programmed cell death. Autophagy genes function in the removal of somatic cell corpses during embryogenesis. Here we demonstrated that autophagy activity participates in germ-cell death induced by genotoxic stress. Upon γ ray treatment, fewer germline cells execute the death program in autophagy mutants. Autophagy also contributes to physiological germ-cell death and post-embryonic cell death in ventral cord neurons when ced-3 caspase activity is partially compromised. Our study reveals that autophagy activity contributes to programmed cell death during C. elegans development. |
| Volume | 9(12) |
| Pages | 1975-82 |
| Published | 2013-12-1 |
| DOI | 10.4161/auto.26152 |
| PII | 26152 |
| PMID | 24185352 |
| MeSH | Animals Apoptosis* Autophagy / physiology* Autophagy / radiation effects Caenorhabditis elegans / physiology* Caenorhabditis elegans / radiation effects Caenorhabditis elegans Proteins / genetics Calcium-Binding Proteins / genetics Caspases / genetics Gamma Rays Germ Cells / physiology Germ Cells / radiation effects Membrane Proteins / genetics Microtubule-Associated Proteins / genetics Mutation Organisms, Genetically Modified |
| IF | 9.77 |
| Times Cited | 18 |
| WOS Category | CELL BIOLOGY |
| Resource | |
| C.elegans | tm3425 tm3077 |