論文 - 詳細
| RRC ID | 46314 |
|---|---|
| 著者 | Pan CL, Peng CY, Chen CH, McIntire S. |
| タイトル | Genetic analysis of age-dependent defects of the Caenorhabditis elegans touch receptor neurons. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Although many genes have been implicated in the pathogenesis of common neurodegenerative diseases, the genetic and cellular mechanisms that maintain neuronal integrity during normal aging remain elusive. Here we show that Caenorhabditis elegans touch receptor and cholinergic neurons display age-dependent morphological defects, including cytoskeletal disorganization, axon beading, and defasciculation. Progression of neuronal aging is regulated by DAF-2 and DAF-16 signaling, which also modulate adult life span. Mutations that disrupt touch-evoked sensory activity or reduce membrane excitability trigger accelerated neuronal aging, indicating that electrical activity is critical for adult neuronal integrity. Disrupting touch neuron attachment to the epithelial cells induces distinct neurodegenerative phenotypes. These results provide a detailed description of the age-dependent morphological defects that occur in identified neurons of C. elegans, demonstrate that the age of onset of these defects is regulated by specific genes, and offer experimental evidence for the importance of normal levels of neural activity in delaying neuronal aging. |
| 巻・号 | 108(22) |
| ページ | 9274-9 |
| 公開日 | 2011-5-31 |
| DOI | 10.1073/pnas.1011711108 |
| PII | 1011711108 |
| PMID | 21571636 |
| PMC | PMC3107274 |
| MeSH | Aging* Animals Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Extracellular Matrix / metabolism Genes, Helminth Insulin / metabolism Microscopy, Fluorescence / methods Models, Biological Mutation Neurodegenerative Diseases Neurons / metabolism* Neurons / physiology* Phenotype Signal Transduction Touch / genetics* |
| IF | 9.412 |
| 引用数 | 67 |
| WOS 分野 | NEUROSCIENCES |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1502 |