論文 - 詳細
| RRC ID | 46420 |
|---|---|
| 著者 | Yoshimura S, Murray JI, Lu Y, Waterston RH, Shaham S. |
| タイトル | mls-2 and vab-3 Control glia development, hlh-17/Olig expression and glia-dependent neurite extension in C. elegans. |
| ジャーナル | Development |
| Abstract |
Glia are essential components of nervous systems. However, genetic programs promoting glia development and regulating glia-neuron interactions have not been extensively explored. Here we describe transcriptional programs required for development and function of the C. elegans cephalic sheath (CEPsh) glia. We demonstrate ventral- and dorsal-restricted roles for the mls-2/Nkx/Hmx and vab-3/Pax6/Pax7 genes, respectively, in CEPsh glia differentiation and expression of the genes hlh-17/Olig and ptr-10/Patched-related. Using mls-2 and vab-3 mutants, as well as CEPsh glia-ablated animals, we show that CEPsh glia are important for sensory dendrite extension, axon guidance/branching within the nerve ring, and nerve ring assembly. We demonstrate that UNC-6/Netrin, expressed in ventral CEPsh glia, mediates glia-dependent axon guidance. Our results suggest possible similarities between CEPsh glia development and oligodendrocyte development in vertebrates, and demonstrate that C. elegans provides a unique environment for studying glial functions in vivo. |
| 巻・号 | 135(13) |
| ページ | 2263-75 |
| 公開日 | 2008-7-1 |
| DOI | 10.1242/dev.019547 |
| PII | dev.019547 |
| PMID | 18508862 |
| MeSH | Amino Acid Sequence Animals Axons / metabolism Caenorhabditis elegans / embryology Caenorhabditis elegans / genetics Caenorhabditis elegans / growth & development* Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / chemistry Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Differentiation Gene Expression Regulation, Developmental Homeodomain Proteins / genetics Homeodomain Proteins / metabolism* Humans Molecular Sequence Data Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism Netrins Neurites Neuroglia / cytology* Neuroglia / metabolism* PAX6 Transcription Factor Paired Box Transcription Factors Phylogeny Sequence Alignment Sequence Homology, Amino Acid Transcription Factors / chemistry Transcription Factors / genetics Transcription Factors / metabolism* Transcription, Genetic / genetics |
| IF | 5.611 |
| 引用数 | 57 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| 線虫 | tm2850 |