Reference - Detail
| RRC ID | 46673 |
|---|---|
| Author | Shinkai Y, Yamamoto Y, Fujiwara M, Tabata T, Murayama T, Hirotsu T, Ikeda DD, Tsunozaki M, Iino Y, Bargmann CI, Katsura I, Ishihara T. |
| Title | Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase, GCY-28, and a receptor tyrosine kinase, SCD-2, in AIA interneurons of Caenorhabditis elegans. |
| Journal | J Neurosci |
| Abstract |
Animals facing conflicting sensory cues make a behavioral choice between competing alternatives through integration of the sensory cues. Here, we performed a genetic screen to identify genes important for the sensory integration of two conflicting cues, the attractive odorant diacetyl and the aversive stimulus Cu(2+), and found that the membrane-bound guanylyl cyclase GCY-28 and the receptor tyrosine kinase SCD-2 regulate the behavioral choice between these alternatives in Caenorhabditis elegans. The gcy-28 mutants and scd-2 mutants show an abnormal bias in the behavioral choice between the cues, although their responses to each individual cue are similar to those in wild-type animals. Mutants in a gene encoding a cyclic nucleotide gated ion channel, cng-1, also exhibit the defect in sensory integration. Molecular genetic analyses suggested that GCY-28 and SCD-2 regulate sensory integration in AIA interneurons, where the conflicting sensory cues may converge. Genetic ablation or hyperpolarization of AIA interneurons showed nearly the same phenotype as gcy-28 or scd-2 mutants in the sensory integration, although this did not affect the sensory response to each individual cue. In gcy-28 or scd-2 mutants, activation of AIA interneurons is sufficient to restore normal sensory integration. These results suggest that the activity of AIA interneurons regulates the behavioral choice between the alternatives. We propose that GCY-28 and SCD-2 regulate sensory integration by modulating the activity of AIA interneurons. |
| Volume | 31(8) |
| Pages | 3007-15 |
| Published | 2011-2-23 |
| DOI | 10.1523/JNEUROSCI.4691-10.2011 |
| PII | 31/8/3007 |
| PMID | 21414922 |
| PMC | PMC6623760 |
| MeSH | Animals Behavior, Animal / physiology* Caenorhabditis elegans / cytology Caenorhabditis elegans / enzymology* Caenorhabditis elegans / genetics Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / physiology* Choice Behavior / physiology* Guanylate Cyclase / genetics Guanylate Cyclase / physiology* Interneurons / cytology Interneurons / enzymology* Membrane Proteins Protein-Tyrosine Kinases / genetics Protein-Tyrosine Kinases / physiology* Receptor Protein-Tyrosine Kinases / genetics Receptor Protein-Tyrosine Kinases / physiology* Receptors, Guanylate Cyclase-Coupled / genetics Receptors, Guanylate Cyclase-Coupled / physiology* |
| IF | 5.674 |
| Times Cited | 51 |
| WOS Category | NEUROSCIENCES |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 9 |
| Altmetric score changes over past 6months | 3.0 |
| Resource | |
| C.elegans | tm2411 tm3028 tm501 |