論文 - 詳細
| RRC ID | 46728 |
|---|---|
| 著者 | Kirienko NV, Fay DS. |
| タイトル | SLR-2 and JMJC-1 regulate an evolutionarily conserved stress-response network. |
| ジャーナル | EMBO J |
| Abstract |
Maintaining a homeostatic interaction with the environment is crucial for the growth, survival, and propagation of all living organisms. Reestablishment of equilibrium after stress is achieved by the activation of complex transcriptional-response networks, many of which remain poorly understood. Here, we report that the zinc-finger protein, SLR-2, is a master stress regulator and is required for the normal response to pleiotropic stress conditions in Caenorhabditis elegans. Using bioinformatical tools, we identified an evolutionarily conserved nucleotide motif present in slr-2 stress-responsive genes and show that this motif is sufficient for stress induction under a variety of conditions. We also demonstrate that JMJC-1, a conserved Jumonji C domain protein, acts downstream of SLR-2 to mediate stress response in C. elegans. Moreover, the role of JMJC-1 in stress response is conserved in Drosophila and mammals. Finally, we provide evidence that the SLR-2-JMJC-1 pathway functions independently of the well-studied DAF-16/FOXO1 network. These findings point to a previously unrecognized phylogenetically conserved master stress-response pathway in metazoa. |
| 巻・号 | 29(4) |
| ページ | 727-39 |
| 公開日 | 2010-2-17 |
| DOI | 10.1038/emboj.2009.387 |
| PII | emboj2009387 |
| PMID | 20057358 |
| PMC | PMC2829162 |
| MeSH | Animals Animals, Genetically Modified Base Sequence Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* DNA, Helminth / genetics Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / metabolism Evolution, Molecular Female Forkhead Transcription Factors / genetics Forkhead Transcription Factors / metabolism Gene Dosage Gene Expression Regulation Genes, Helminth Humans Jumonji Domain-Containing Histone Demethylases / genetics Jumonji Domain-Containing Histone Demethylases / metabolism* Male Mammals Recombinant Fusion Proteins / genetics Recombinant Fusion Proteins / metabolism Sequence Homology, Nucleic Acid Species Specificity Stress, Physiological Transcription Factors / genetics Transcription Factors / metabolism |
| IF | 9.889 |
| 引用数 | 20 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| 線虫 | tm3525 |