Reference - Detail
| RRC ID | 4792 |
|---|---|
| Author | Suzuki K, Takahashi S, Haramoto Y, Onuma Y, Nagamine K, Okabayashi K, Hashizume K, Iwanaka T, Asashima M. |
| Title | XRASGRP2 is essential for blood vessel formation during Xenopus development. |
| Journal | Int J Dev Biol |
| Abstract |
Ras guanyl nucleotide-releasing protein 2 (RASGRP2), one of the Ras guanine exchange factors, is implicated as a critical regulator of inside-out integrin activation in human lymphocytes, neutrophils and platelets. However, the activities of this protein in endothelial cells remain unclear. In the current study, we identify a physiological function in blood vessel formation for XRASGRP2, which is the Xenopus ortholog of mammalian RASGRP2. XRASGRP2 over-expression induced ectopic vascular formation, and XRASGRP2-knockdown embryos showed delayed vascular development. We also investigated the upstream signaling of XRASGRP2 in endothelium formation. XRASGRP2 expression was up-regulated in the presence of VEGF-A and down-regulated following VEGF-A depletion. XRASGRP2 knockdown abolished the ectopic induction of endothelial cells by VEGF-A in the posterior ventral blood island. These results suggest that XRASGRP2 is essential for vascular formation during Xenopus development. |
| Volume | 54(4) |
| Pages | 609-15 |
| Published | 2010-1-1 |
| DOI | 10.1387/ijdb.092929ks |
| PII | 092929ks |
| PMID | 19598105 |
| MeSH | Animals Blood Vessels / metabolism* Cell Differentiation / genetics Endothelial Cells / metabolism Guanine Nucleotide Exchange Factors / genetics Guanine Nucleotide Exchange Factors / metabolism Humans Signal Transduction / physiology Vascular Endothelial Growth Factor A / genetics Vascular Endothelial Growth Factor A / metabolism Xenopus / genetics Xenopus / metabolism* Xenopus Proteins / genetics Xenopus Proteins / physiology* ras Guanine Nucleotide Exchange Factors / genetics ras Guanine Nucleotide Exchange Factors / physiology* |
| IF | 1.105 |
| Times Cited | 6 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
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| Total number of mentions | 0 |
| Resource | |
| Clawed frogs / Newts | |