論文 - 詳細
| RRC ID | 4792 |
|---|---|
| 著者 | Suzuki K, Takahashi S, Haramoto Y, Onuma Y, Nagamine K, Okabayashi K, Hashizume K, Iwanaka T, Asashima M. |
| タイトル | XRASGRP2 is essential for blood vessel formation during Xenopus development. |
| ジャーナル | Int J Dev Biol |
| Abstract |
Ras guanyl nucleotide-releasing protein 2 (RASGRP2), one of the Ras guanine exchange factors, is implicated as a critical regulator of inside-out integrin activation in human lymphocytes, neutrophils and platelets. However, the activities of this protein in endothelial cells remain unclear. In the current study, we identify a physiological function in blood vessel formation for XRASGRP2, which is the Xenopus ortholog of mammalian RASGRP2. XRASGRP2 over-expression induced ectopic vascular formation, and XRASGRP2-knockdown embryos showed delayed vascular development. We also investigated the upstream signaling of XRASGRP2 in endothelium formation. XRASGRP2 expression was up-regulated in the presence of VEGF-A and down-regulated following VEGF-A depletion. XRASGRP2 knockdown abolished the ectopic induction of endothelial cells by VEGF-A in the posterior ventral blood island. These results suggest that XRASGRP2 is essential for vascular formation during Xenopus development. |
| 巻・号 | 54(4) |
| ページ | 609-15 |
| 公開日 | 2010-1-1 |
| DOI | 10.1387/ijdb.092929ks |
| PII | 092929ks |
| PMID | 19598105 |
| MeSH | Animals Blood Vessels / metabolism* Cell Differentiation / genetics Endothelial Cells / metabolism Guanine Nucleotide Exchange Factors / genetics Guanine Nucleotide Exchange Factors / metabolism Humans Signal Transduction / physiology Vascular Endothelial Growth Factor A / genetics Vascular Endothelial Growth Factor A / metabolism Xenopus / genetics Xenopus / metabolism* Xenopus Proteins / genetics Xenopus Proteins / physiology* ras Guanine Nucleotide Exchange Factors / genetics ras Guanine Nucleotide Exchange Factors / physiology* |
| IF | 1.105 |
| 引用数 | 6 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ツメガエル・イモリ | |