RRC ID 48852
Author Renault-Mihara F, Mukaino M, Shinozaki M, Kumamaru H, Kawase S, Baudoux M, Ishibashi T, Kawabata S, Nishiyama Y, Sugai K, Yasutake K, Okada S, Nakamura M, Okano H.
Title Regulation of RhoA by STAT3 coordinates glial scar formation.
Journal J. Cell Biol.
Abstract mice. These findings reveal novel intracellular signaling mechanisms underlying the contribution of reactive astrocyte dynamics to glial scar formation.
Volume 216(8)
Pages 2533-2550
Published 2017-8-7
DOI 10.1083/jcb.201610102
PII jcb.201610102
PMID 28642362
PMC PMC5551705
MeSH Actomyosin / metabolism Animals Animals, Newborn Astrocytes / enzymology* Astrocytes / pathology Cell Adhesion Cell Movement Cells, Cultured Cicatrix / enzymology* Cicatrix / genetics Cicatrix / pathology Coculture Techniques Cytoskeletal Proteins / genetics Cytoskeletal Proteins / metabolism Disease Models, Animal Genotype Integrases / genetics Macrophages / metabolism Matrix Metalloproteinase 2 / genetics Matrix Metalloproteinase 2 / metabolism Mice, Inbred C57BL Mice, Knockout MicroRNAs / genetics MicroRNAs / metabolism Nestin / genetics Neuroglia / enzymology* Neuroglia / pathology PTEN Phosphohydrolase / genetics PTEN Phosphohydrolase / metabolism Phenotype Phosphorylation Proteolysis STAT3 Transcription Factor / deficiency STAT3 Transcription Factor / genetics STAT3 Transcription Factor / metabolism* Signal Transduction Spinal Cord / enzymology* Spinal Cord / pathology Spinal Cord Injuries / enzymology* Spinal Cord Injuries / genetics Spinal Cord Injuries / pathology Transfection Wounds, Stab / enzymology* Wounds, Stab / genetics Wounds, Stab / pathology rho GTP-Binding Proteins / genetics rho GTP-Binding Proteins / metabolism* rho-Associated Kinases / metabolism
IF 8.784
Resource
Mice B6.129P2-Pten<tm2Mak>(RBRC02300)