論文 - 詳細
| RRC ID | 51425 |
|---|---|
| 著者 | Ryu JS, Koo HS. |
| タイトル | The Caenorhabditis elegans WRN helicase promotes double-strand DNA break repair by mediating end resection and checkpoint activation. |
| ジャーナル | FEBS Lett |
| Abstract |
The protein associated with Werner syndrome (WRN), is involved in DNA repair, checkpoint activation, and telomere maintenance. To better understand the involvement of WRN in double-strand DNA break (DSB) repair, we analyzed the combinatorial role of WRN-1, the Caenorhabditis elegans WRN helicase, in conjunction with EXO-1 and DNA-2 nucleases. We found that WRN-1 cooperates with DNA-2 to resect DSB ends in a pathway acting in parallel to EXO-1. The wrn-1 mutants show an aberrant accumulation of replication protein A (RPA) and RAD-51, and the same pattern of accumulation is also observed in checkpoint-defective strains. We conclude that WRN-1 plays a conserved role in the resection of DSB ends and mediates checkpoint signaling, thereby influencing levels of RPA and RAD-51. |
| 巻・号 | 591(14) |
| ページ | 2155-2166 |
| 公開日 | 2017-7-1 |
| DOI | 10.1002/1873-3468.12724 |
| PMID | 28640365 |
| MeSH | Animals Caenorhabditis elegans / cytology Caenorhabditis elegans / enzymology* Caenorhabditis elegans / genetics* Caenorhabditis elegans / radiation effects Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Cycle Checkpoints* / radiation effects DNA Breaks, Double-Stranded* DNA Helicases / genetics DNA Helicases / metabolism* DNA Repair* / radiation effects Endodeoxyribonucleases / genetics Endodeoxyribonucleases / metabolism Gamma Rays Mutation Rad51 Recombinase / metabolism Replication Protein A / metabolism |
| IF | 3.057 |
| 引用数 | 4 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1842 |