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  • Search Condition : Filter (MeSH = DNA Breaks, Double-Stranded*)
Species Resource
C.elegans tm750 Targeted engineering of the Caenorhabditis elegans genome following Mos1-triggered chromosomal breaks.
C.elegans tm1145 BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair.
C.elegans tm1086 HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosis.
DNA material S. pombe YFP-FLAG-His , SpYFH06D01 (SPW082473) , SpYFH25C07 (SPW090055). A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks.
Drosophila The balancer chromosomes were CyO and TM3 (Kyoto Stock Center). The double-stranded break-forming activity of plant SPO11s and a novel rice SPO11 revealed by a Drosophila bioassay.
C.elegans tm5034 , tm1268 , tm611 , tm574 , tm3655 Identification of DSB-1, a protein required for initiation of meiotic recombination in Caenorhabditis elegans, illuminates a crossover assurance checkpoint.
Human and Animal Cells MOLT-4 (RCB0206) Induction of in situ DNA double-strand breaks and apoptosis by 200 MeV protons and 10 MV X-rays in human tumour cell lines.
Human and Animal Cells HeLa.S3 (RCB0191) CHO-K1 (RCB0285) Accumulation of p21 proteins at DNA damage sites independent of p53 and core NHEJ factors following irradiation.
Arabidopsis / Cultured plant cells, genes rpc00008 Arabidopsis replication protein A 70a is required for DNA damage response and telomere length homeostasis.
C.elegans tm1145 , tm2073 A robust network of double-strand break repair pathways governs genome integrity during C. elegans development.
Human and Animal Cells Cyclin A overexpression induces chromosomal double-strand breaks in mammalian cells.
C.elegans tm2334 Loading of meiotic cohesin by SCC-2 is required for early processing of DSBs and for the DNA damage checkpoint.
C.elegans tm2940 , tm1579 , tm853 , tm1670 , tm899 The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair.
DNA material CSII-EF-MCS-IRES-hrGFP (RDB04382) , CSII-CMV-MCS (RDB04377) DNA double strand break repair enzymes function at multiple steps in retroviral infection.
C.elegans tm1842 Impaired resection of meiotic double-strand breaks channels repair to nonhomologous end joining in Caenorhabditis elegans.
C.elegans tm574 , tm1813 , tm583 Meiotic errors activate checkpoints that improve gamete quality without triggering apoptosis in male germ cells.
C.elegans tm1842 The Caenorhabditis elegans WRN helicase promotes double-strand DNA break repair by mediating end resection and checkpoint activation.
Human and Animal Cells L5178Y(RCB0135) , M10(RCB0136) In cellulo phosphorylation of DNA double-strand break repair protein XRCC4 on Ser260 by DNA-PK.
DNA material AxCANCre (RDB01748) The CDKN1B-RB1-E2F1 pathway protects mouse spermatogonial stem cells from genomic damage.
Human and Animal Cells A549(RCB0098) , WI-38(RCB0702) Enhanced DNA double-strand break repair of microbeam targeted A549 lung carcinoma cells by adjacent WI38 normal lung fibroblast cells via bi-directional signaling.