RRC ID 52161
Author Packer LM, Geng X, Bonazzi VF, Ju RJ, Mahon CE, Cummings MC, Stephenson SA, Pollock PM.
Title PI3K Inhibitors Synergize with FGFR Inhibitors to Enhance Antitumor Responses in FGFR2mutant Endometrial Cancers.
Journal Mol. Cancer Ther.
Abstract .
Volume 16(4)
Pages 637-648
Published 2017-4
DOI 10.1158/1535-7163.MCT-16-0415
PII 1535-7163.MCT-16-0415
PMID 28119489
MeSH Aminopyridines / administration & dosage* Aminopyridines / pharmacology Animals Antineoplastic Combined Chemotherapy Protocols / administration & dosage* Antineoplastic Combined Chemotherapy Protocols / pharmacology Cell Line, Tumor Cell Proliferation / drug effects Cell Survival / drug effects Drug Synergism Endometrial Neoplasms / drug therapy* Endometrial Neoplasms / genetics Female Gene Expression Regulation, Neoplastic / drug effects Humans Indazoles / administration & dosage* Indazoles / pharmacology Mice Morpholines / administration & dosage* Morpholines / pharmacology Mutation Phenylurea Compounds / administration & dosage* Phenylurea Compounds / pharmacology Phosphatidylinositol 3-Kinases / antagonists & inhibitors Pyrimidines / administration & dosage* Pyrimidines / pharmacology Receptor, Fibroblast Growth Factor, Type 2 / antagonists & inhibitors Receptor, Fibroblast Growth Factor, Type 2 / genetics* Sulfonamides / administration & dosage* Sulfonamides / pharmacology Thiazoles / administration & dosage* Thiazoles / pharmacology Xenograft Model Antitumor Assays
IF 5.365
Resource
Human and Animal Cells JHUEM-2(RCB1551)