論文 - 詳細
| RRC ID | 53254 |
|---|---|
| 著者 | Shen Y, Ng LF, Low NP, Hagen T, Gruber J, Inoue T. |
| タイトル | C. elegans miro-1 Mutation Reduces the Amount of Mitochondria and Extends Life Span. |
| ジャーナル | PLoS One |
| Abstract |
Mitochondria play a critical role in aging, however, the underlying mechanism is not well understood. We found that a mutation disrupting the C. elegans homolog of Miro GTPase (miro-1) extends life span. This phenotype requires simultaneous loss of miro-1 from multiple tissues including muscles and neurons, and is dependent on daf-16/FOXO. Notably, the amount of mitochondria in the miro-1 mutant is reduced to approximately 50% of the wild-type. Despite this reduction, oxygen consumption is only weakly reduced, suggesting that mitochondria of miro-1 mutants are more active than wild-type mitochondria. The ROS damage is slightly reduced and the mitochondrial unfolded protein response pathway is weakly activated in miro-1 mutants. Unlike previously described long-lived mitochondrial electron transport chain mutants, miro-1 mutants have normal growth rate. These results suggest that the reduction in the amount of mitochondria can affect the life span of an organism through activation of stress pathways. |
| 巻・号 | 11(4) |
| ページ | e0153233 |
| 公開日 | 2016-1-1 |
| DOI | 10.1371/journal.pone.0153233 |
| PII | PONE-D-16-07739 |
| PMID | 27064409 |
| PMC | PMC4827821 |
| MeSH | Aging / genetics Animals Caenorhabditis elegans / genetics* Caenorhabditis elegans / growth & development Caenorhabditis elegans / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Longevity / genetics* Mitochondria / metabolism Mitochondria / pathology* Mitochondrial Proteins / genetics Mitochondrial Proteins / metabolism* Mutation / genetics* Oxygen Consumption Phenotype RNA, Messenger / genetics Reactive Oxygen Species / metabolism Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Signal Transduction |
| IF | 2.74 |
| 引用数 | 10 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1966 |