論文 - 詳細
| RRC ID | 54834 |
|---|---|
| 著者 | Uzawa K, Kasamatsu A, Saito T, Kita A, Sawai Y, Toeda Y, Koike K, Nakashima D, Endo Y, Shiiba M, Takiguchi Y, Tanzawa H. |
| タイトル | Growth suppression of human oral cancer cells by candidate agents for cetuximab-side effects. |
| ジャーナル | Exp Cell Res |
| Abstract |
Cetuximab, an inhibitor of the epidermal growth factor receptor that is used widely to treat human cancers including oral squamous cell carcinoma (OSCC), has characteristic side effects of skin rash and hypomagnesemia. However, the mechanisms of and therapeutic agents for skin rashes and hypomagnesemia are still poorly understood. Our gene expression profiling analyses showed that cetuximab activates the p38 MAPK pathways in human skin cells (human keratinocyte cell line [HaCaT]) and inhibits c-Fos-related signals in human embryonic kidney cells (HEK293). We found that while the p38 inhibitor SB203580 inhibited the expression of p38 MAPK targets in HaCaT cells, flavagline reactivated c-Fos-related factors in HEK293 cells. It is noteworthy that, in addition to not interfering with the effect of cetuximab by both compounds, flavagline has additive effect for OSCC growth inhibition in vivo. Collectively, our results indicate that combination of cetuximab and these potential therapeutic agents for cetuximab-related toxicities could be a promising therapeutic strategy for patients with OSCC. |
| 巻・号 | 376(2) |
| ページ | 210-220 |
| 公開日 | 2019-3-15 |
| DOI | 10.1016/j.yexcr.2019.01.016 |
| PII | S0014-4827(19)30021-7 |
| PMID | 30690028 |
| MeSH | Animals Antineoplastic Agents, Immunological / adverse effects* Carcinoma, Squamous Cell / complications Carcinoma, Squamous Cell / drug therapy* Cell Line, Tumor Cetuximab / adverse effects* Drug Therapy, Combination ErbB Receptors / antagonists & inhibitors Exanthema / chemically induced Exanthema / genetics Exanthema / prevention & control Female Gene Expression Regulation, Neoplastic / drug effects Gene Regulatory Networks Growth Inhibitors / adverse effects Growth Inhibitors / antagonists & inhibitors Growth Inhibitors / therapeutic use* HEK293 Cells Humans Hypercalciuria / chemically induced Hypercalciuria / genetics Hypercalciuria / prevention & control Imidazoles / therapeutic use* MAP Kinase Signaling System / drug effects Mice Mice, Inbred BALB C Mice, Nude Mouth Neoplasms / complications Mouth Neoplasms / drug therapy* Mouth Neoplasms / genetics Nephrocalcinosis / chemically induced Nephrocalcinosis / genetics Nephrocalcinosis / prevention & control Pyridines / therapeutic use* Renal Tubular Transport, Inborn Errors / chemically induced Renal Tubular Transport, Inborn Errors / genetics Renal Tubular Transport, Inborn Errors / prevention & control Transcriptome Xenograft Model Antitumor Assays |
| IF | 3.329 |
| 引用数 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | Sa3(RCB0980) SAS(RCB1974) |