論文 - 詳細
RRC ID | 5629 |
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著者 | Bossuyt W, De Geest N, Aerts S, Leenaerts I, Marynen P, Hassan BA. |
タイトル | The atonal proneural transcription factor links differentiation and tumor formation in Drosophila. |
ジャーナル | PLoS Biol |
Abstract |
The acquisition of terminal cell fate and onset of differentiation are instructed by cell type-specific master control genes. Loss of differentiation is frequently observed during cancer progression, but the underlying causes and mechanisms remain poorly understood. We tested the hypothesis that master regulators of differentiation may be key regulators of tumor formation. Using loss- and gain-of-function analyses in Drosophila, we describe a critical anti-oncogenic function for the atonal transcription factor in the fly retina, where atonal instructs tissue differentiation. In the tumor context, atonal acts by regulating cell proliferation and death via the JNK stress response pathway. Combined with evidence that atonal's mammalian homolog, ATOH1, is a tumor suppressor gene, our data support a critical, evolutionarily conserved, function for ato in oncogenesis. |
巻・号 | 7(2) |
ページ | e40 |
公開日 | 2009-2-24 |
DOI | 10.1371/journal.pbio.1000040 |
PII | 08-PLBI-RA-3802 |
PMID | 19243220 |
PMC | PMC2652389 |
MeSH | Animals Apoptosis / genetics Basic Helix-Loop-Helix Transcription Factors / genetics* Basic Helix-Loop-Helix Transcription Factors / metabolism Body Patterning / genetics Cell Differentiation / genetics Cell Transformation, Neoplastic / genetics* Drosophila* / embryology Drosophila* / genetics Drosophila Proteins / genetics Drosophila Proteins / metabolism Eye Neoplasms / genetics* Eye Neoplasms / metabolism Gene Expression Regulation, Developmental* Gene Expression Regulation, Neoplastic* Gene Silencing Nerve Tissue Proteins / genetics* Nerve Tissue Proteins / metabolism Organisms, Genetically Modified Retina / cytology Retina / embryology |
IF | 7.076 |
引用数 | 35 |
WOS 分野 | BIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
リソース情報 | |
ショウジョウバエ |