RRC ID |
5639
|
著者 |
Ribaya JP, Ranmuthu M, Copeland J, Boyarskiy S, Blair AP, Hay B, Laski FA.
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タイトル |
The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila.
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ジャーナル |
Dev Biol
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Abstract |
We have characterized the gene emperor's thumb (et) and showed that it is required for the regulation of apoptosis in Drosophila. Loss-of-function mutations in et result in apoptosis associated with a decrease in the concentration of DIAP1. Overexpression of one form of et inhibits apoptosis, consistent with et having an anti-apoptotic function; however, overexpression of a second form of et induces apoptosis, indicating that the two forms of et may have competing functions. et encodes a protein deubiquitinase, suggesting it regulates apoptosis by controlling the stability of apoptotic regulatory proteins.
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巻・号 |
329(1)
|
ページ |
25-35
|
公開日 |
2009-5-1
|
DOI |
10.1016/j.ydbio.2009.02.005
|
PII |
S0012-1606(09)00107-9
|
PMID |
19217892
|
MeSH |
Amino Acid Sequence
Animals
Apoptosis / physiology*
Apoptosis Regulatory Proteins / physiology*
Drosophila / genetics
Drosophila / metabolism*
Drosophila Proteins / physiology*
Endopeptidases / physiology*
Genes, Insect*
Models, Biological
Molecular Sequence Data
Mutation
Phylogeny
Protein Structure, Tertiary
Sequence Homology, Amino Acid
Ubiquitin-Protein Ligases / metabolism
|
IF |
2.896
|
引用数 |
12
|
WOS 分野
|
DEVELOPMENTAL BIOLOGY
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リソース情報 |
ショウジョウバエ |
|