RRC ID 5639
Author Ribaya JP, Ranmuthu M, Copeland J, Boyarskiy S, Blair AP, Hay B, Laski FA.
Title The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila.
Journal Dev Biol
Abstract We have characterized the gene emperor's thumb (et) and showed that it is required for the regulation of apoptosis in Drosophila. Loss-of-function mutations in et result in apoptosis associated with a decrease in the concentration of DIAP1. Overexpression of one form of et inhibits apoptosis, consistent with et having an anti-apoptotic function; however, overexpression of a second form of et induces apoptosis, indicating that the two forms of et may have competing functions. et encodes a protein deubiquitinase, suggesting it regulates apoptosis by controlling the stability of apoptotic regulatory proteins.
Volume 329(1)
Pages 25-35
Published 2009-5-1
DOI 10.1016/j.ydbio.2009.02.005
PII S0012-1606(09)00107-9
PMID 19217892
MeSH Amino Acid Sequence Animals Apoptosis / physiology* Apoptosis Regulatory Proteins / physiology* Drosophila / genetics Drosophila / metabolism* Drosophila Proteins / physiology* Endopeptidases / physiology* Genes, Insect* Models, Biological Molecular Sequence Data Mutation Phylogeny Protein Structure, Tertiary Sequence Homology, Amino Acid Ubiquitin-Protein Ligases / metabolism
IF 2.896
Times Cited 12
WOS Category DEVELOPMENTAL BIOLOGY
Resource
Drosophila