Reference - Detail
| RRC ID | 5639 |
|---|---|
| Author | Ribaya JP, Ranmuthu M, Copeland J, Boyarskiy S, Blair AP, Hay B, Laski FA. |
| Title | The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila. |
| Journal | Dev Biol |
| Abstract |
We have characterized the gene emperor's thumb (et) and showed that it is required for the regulation of apoptosis in Drosophila. Loss-of-function mutations in et result in apoptosis associated with a decrease in the concentration of DIAP1. Overexpression of one form of et inhibits apoptosis, consistent with et having an anti-apoptotic function; however, overexpression of a second form of et induces apoptosis, indicating that the two forms of et may have competing functions. et encodes a protein deubiquitinase, suggesting it regulates apoptosis by controlling the stability of apoptotic regulatory proteins. |
| Volume | 329(1) |
| Pages | 25-35 |
| Published | 2009-5-1 |
| DOI | 10.1016/j.ydbio.2009.02.005 |
| PII | S0012-1606(09)00107-9 |
| PMID | 19217892 |
| MeSH | Amino Acid Sequence Animals Apoptosis / physiology* Apoptosis Regulatory Proteins / physiology* Drosophila / genetics Drosophila / metabolism* Drosophila Proteins / physiology* Endopeptidases / physiology* Genes, Insect* Models, Biological Molecular Sequence Data Mutation Phylogeny Protein Structure, Tertiary Sequence Homology, Amino Acid Ubiquitin-Protein Ligases / metabolism |
| IF | 2.896 |
| Times Cited | 12 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| Drosophila | |